中药致肾损伤的CiteSpace科学文献可视化分析

Visualization of research on Chinese medicine-induced kidney injury by CiteSpace

为供研究者了解中药致肾损伤的研究现状、研究进展及问题,运用知识图谱直观展示该领域的研究历程,发现其研究热点与前沿,为进一步开展后续的研究提供参考与指引方向。检索中国知网从建库至2020年11月20日收录的相关文献,最终纳入文献683篇进行可视化分析,采用CiteSpace绘制其关键词、研究机构、作者的知识图谱。从2006年至今,中药致肾损伤的年发文量呈平稳下降的趋势;共现频次排名前5的关键词有肾小管-间质性肾炎、马兜铃酸、木通、实验性研究、描述性研究;共现频次及突现强度最高的中药关键词为木通;突现结束年份为2020年且突现强度最高的中药关键词为雷公藤及其制剂。可见,木通为中药致肾损伤的研究热点,雷公藤为研究前沿。目前研究内容主要集中在"有机阴离子转运体""代谢组学"。中药致肾损伤研究数量的逐渐减少考虑为随着中药致肾损伤研究的深入,相关的临床病例报告减少,但仍需要开展更多的临床研究,可运用药物警戒的理念和方法,构建中药药物警戒体系,主动和被动地监测和收集中药致肾损伤的临床病例,得到中药致肾损伤的不良反应发生率和发生特征,进行全方位、多维度的安全性研究。

This study aimed to provide researchers with a better understanding of the research status, progress and problems of Chinese medicine-induced kidney injury. The mapping knowledge domain(MKD) was chosen to visualize the research process, hotspots,and frontiers, thus providing a reference for follow-up research. The relevant articles were retrieved from China National Knowledge Infrastructure(CNKI) from its inception to November 20, 2020, and 683 were finally included for visualization, with a knowledge map covering the keywords, research institutions and authors plotted by Cite Space. Since 2006, the annual number of published articles regarding Chinese medicine-induced kidney injury has steadily declined. The top five keywords sorted by frequency of co-occurrence were tubulointerstitial nephritis(TIN), aristolochic acid(AA), Akebiae Caulis, experimental research, and descriptive research. Akebiae Caulis appeared at the highest frequency of co-occurrence among Chinese medicines and exhibited the highest burst intensity. The burst ended in 2020, when the Chinese medicine with the highest burst intensity changed to Tripterygii wilfordii and its preparations. It could be seen that Akebiae Caulis was the hotspot in the research of Chinese medicine-induced kidney injury, and T. wilfordii became the research frontier. The current research has mainly focused on " organic anion transporters" and " metabolomics". The decline in articles about Chinese medicine-induced kidney injury was attributed to the reduced clinical case reports after the in-depth study of Chinese medicine-induced kidney injury. However, more clinical studies need to be conducted based on the concept and method of pharmacovigilance to construct a pharmacovigilance system of Chinese medicine for actively and passively monitoring and collecting the clinical cases with Chinese medicine-induced kidney injury, figuring out the incidence and characteristics of adverse reactions caused by Chinese medicine, and carrying out comprehensive and multi-dimensional safety research.