立体定向放疗用于结直肠癌肝与肺寡转移的研究进展

Stereotactic body radiation therapy for liver and lung oligometastases from colorectal cancer:safety,local efficacy and prognostic factors

寡转移是肿瘤从局部区域病变进展到远处广泛转移过程中存在的一种中间状态,通过局部治疗有获得长期生存的可能。体部立体定向放疗(SBRT)单次剂量高、分割次数少,是一种高精准的局部消融治疗手段。结直肠癌有近一半患者会发生转移,主要转移部位为肝和肺。本文主要阐述SBRT治疗结直肠癌肝、肺寡转移灶的安全性、近期疗效及其影响因素,同时也总结了SBRT具体实施的要点。SBRT在严格的呼吸运动管理和放疗质控下是治疗结直肠癌寡转移的有效手段。

Oligometastasis is an intermediate status between the locally advanced and wide spread disease.Patients with oligometastasis may obtain long-term survival after local treatment.Stereotactic body radiation therapy(SBRT)can deliver radical ablative doses in a small number of fractions,which is a highly precise local ablation therapy.Approximately half of patients diagnosed with colorectal cancer(CRC)will develop metastases,with the liver and lung as the most common site of involvement.In this article,the safety,local efficacy and prognostic factors of SBRT for liver and lung oligometastases from CRC were illustrated.The highlights of SBRT implementation were also discussed.SBRT is safe and effective for oligometastases from CRC under respiratory motion management and robust quality assurance.