肿瘤热疗生物学机制研究进展

Research progress on biological mechanism of tumor hyperthermia

近年来肿瘤热疗主要作为肿瘤传统治疗的辅助疗法成为研究热点。热疗可直接诱导肿瘤细胞坏死或凋亡,或通过破坏肿瘤血管抑制其进展,同时热疗还能激活机体免疫系统的免疫细胞和细胞因子的反应,从而调节肿瘤微环境的免疫状态。多种效应相联合共同影响肿瘤的进展。深入了解肿瘤热疗的生物学机制有利于开展新的治疗方法,本文主要对热疗杀灭肿瘤的生物学机制做一综述。

In recent years,tumor hyperthermia has become a hot research topic as an adjuvant therapy to traditional tumor therapy.Hyperthermia can directly induce tumor cell necrosis or apoptosis,or inhibit tumor progression by destroying tumor blood vessels.Meantime,it can also activate the response of immune cells and cytokines in the immune system of the host,thereby regulating the immune state of tumor microenvironment.Multiple combined effects influence the tumor progression.A thorough understanding of the biological mechanism of hyperthermia is beneficial to the development of novel therapeutic methods.In this paper,the biological mechanism of hyperthermia in killing tumors was mainly reviewed.