摘要
DNA损伤修复基因在维持基因组的完整性、细胞功能的特异性和预防细胞癌变过程中发挥着重要作用。近年来越来越多的研究发现DNA暴露在紫外线照射环境中损伤后的修复能力与恶性黑色素瘤发生具有显著相关性。本文就DNA损伤修复系统中核苷酸切除修复(nucleotide excision repair,NER)通路和双链断裂修复(doublestrand breaks repair,DSBR)通路中的几类关键基因与恶性黑色素瘤发生发展关系的研究成果进行综述。
DNA damage repair genes play important roles in protecting somatic DNA mutations, and in maintaining the stability and integrity of human genomes. In recent years, a growing number of studies have found that DNA repair capacity after exposure to UV exposure was significantly associated with the risk of malignant melanoma. This article reviews the advances in research on the relationship between the development of DNA malignant melanoma and damage repair genes involving nucleotide excision repair and double-strand breaks repair.
作者
朱公建
王晓敏
郭红云
朱小康
苏海翔
刘玉琴
Zhu Gongjian;Wang Xiaomin;Guo Hongyun;Zhu Xiaokang;Su Haixiang;Liu Yuqin(Department of Science and Education,Gansu Provincial Cancer Hospital&Gansu Provincial Academic Insti-tute of Medical Research,Lanzhou 730050,Gansu,China;Department of Translational Medicine,Gansu Provincial Cancer Hospital&Gansu Provincial Academic Institute of Medical Research,Lanzhou 730050,Gansu,China;Department of Thoracic Surgery,Gansu Provincial Cancer Hospital&Gansu Provincial Academic Institute of Medical Research,Lanzhou 730050,Gansu,China;Department of Cancer Epidemiology,Gansu Provincial Cancer Hospital&Gansu Provincial Academic Institute of Medical Research,Lanzhou 730050,Gansu,China;Department of Medical Affairs,Xigu Hospital(i.e.Second Hospital of Lanzhou University,or People’s Hospital of Xigu District,Lanzhou),Lanzhou 730060,Gansu,China)
出处
《肿瘤预防与治疗》
2021年第11期1069-1073,共5页
Journal of Cancer Control And Treatment
基金
甘肃省重点研发计划项目(编号:17YF1FA111)。
