自噬与肿瘤干细胞放疗抵抗的研究进展

Research Progress in the Relationship between A utophagy and Radioresistance of Cancer Stem Cells

放射治疗是恶性肿瘤治疗的重要方法之一。部分类型的恶性肿瘤经放疗后易产生放疗抵抗。究其原因,包括肿瘤组织缺氧程度、细胞DNA损伤修复能力、上皮间质转化等因素。肿瘤干细胞(cancer stem cells,CSCs)具有的“干性”可能是肿瘤放疗抵抗的原因之一。最新研究显示,自噬在维持CSCs干性机制中发挥重要作用,且已有研究报道了CSCs、细胞自噬、放疗抵抗三者之间关系密切。本文回顾近年来此相关领域的研究热点,对CSCs、细胞自噬、放疗抵抗三者的关系进行了综述,旨在为今后的研究提供新的理论方向。

Radiotherapy is one of the important treatment of malignant tumors.Some types of malignant tumors are prone to be radioresistance after radiotherapy.The reasons include the degree of hypoxia in tumor tissue,the ability of cells to repair DNA damage,epithelial-mesenchymal transformation and other factors.The‘stemness’of cancer stem cells(CSCs)may be one of the reasons for tumor radioresistance.Recent studies have shown that autophagy plays an important role in maintaining the stemness of CSCs,and it is reported that there is a close relationship among CSCs,cell autophagy and radioresistance.This paper reviews recent research hotspots in this field,and summarizes the relationship among CSCs,autophagy and radioresistance,in order to lay a theoretical foundation for future research.