肠道菌群介导生酮饮食治疗作用的研究进展

Advance on therapeutic effects of ketogenic diet mediated by intestinal flora

生酮饮食(KD)是一种含低碳水化合物高脂肪和低蛋白的饮食结构,目前已用于治疗神经系统疾病肿瘤、代谢性疾病、肠道炎症等,但具体机制未明确。肠道菌群是调节宿主活动的重要微生物群,被称为人体第二基因组,肠道菌群紊乱与许多疾病相关,饮食模式是肠道菌群变化的主要驱动因素,许多研究表明KD可能通过调控肠道菌发挥上述治疗作用。文章主要就肠道菌群介导KD治疗作用的研究进展进行综述。

Ketogenie diet(KD)is a diet structure containing low cearbohydrates,high fat and low protein,which has been used to treat nervous system diseascs,lumors,metabolic diseases and intestinal inflammation,but the specific mechanism is not clear.Intestinal microbiota is an important microbiota regulating host activities,known as the second genome of human body.Intestinal flora disorder is associated with many diseases,and dietary patter is the main driving factor of intestinal microbiota changes.Many studies have shown that KD may exert the above therapeutie ffects by regulating intestinal bacteria.This article reviews the progress of the treatment of KD mediated by intestinal flora.