宣白承气汤治疗对重症肺炎患者CRP、TNF-α、IgG、IL-6及中医证候积分的影响

Effect of Xuanbai Chengqi Decoction on CRP,TNF-α,IgG,IL-6 and TCM Syndrome Scores for Patients with Severe Pneumonia

目的:分析宣白承气汤治疗对重症肺炎患者C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、免疫球蛋白G(IgG)、白细胞介素-6(IL-6)及中医证候积分的影响。方法:选取80例重症肺炎患者,按照组间基本特征具有可比性的原则分为对照组(40例)与实验组(40例),对照组仅接受常规西医治疗,实验组则在常规西医治疗的同时,采用宣白承气汤治疗。结果:实验组的临床总有效率为92.5%,明显高于对照组的72.5%(P<0.05)。与对照组相比,实验组的各症状(持续高热、气喘、咳嗽咯痰)缓解时间均明显缩短(P<0.05)。与治疗前相比,治疗后两组的CPIS评分、APACHE II评分以及中医证候积分均明显降低(P<0.05);而且与对照组相比,实验组治疗后的CPIS评分、APACHE II评分以及中医证候积分降低幅度更加明显(P<0.05)。与治疗前相比,治疗后两组的CRP、TNF-α、IL-6水平均明显降低(P<0.05),IgG水平则明显升高(P<0.05);与对照组相比,实验组治疗后的CRP、TNF-α、IL-6水平降低幅度以及IgG水平升高幅度更加明显(P<0.05)。结论:选择宣白承气汤对重症肺炎患者进行治疗能取得比较显著的临床疗效,不但能对炎症反应进行有效抑制,让机体免疫功能显著提高,而且还能对患者临床症状及预后进行显著改善,具有临床推广价值。

Objective:To analyze the effect of Xuanbai Chengqi Decoction on C-reactive protein(CRP),tumor necrosis factorα(TNF-α),immunoglobulin G(IgG),interleukin-6(IL-6)and TCM syndrome scores for patients with severe pneumonia.Methods:Eighty patients with severe pneumonia were selected and divided into a controlled group(40 cases)and an experimental group(40 cases)according to the principle of comparability of basic characteristics between groups.The controlled group only received conventional western medicine treatment,while the experimental group was treated with Xuanbai Chengqi Decoction at the same time of conventional western medicine treatment.Results:The total effective rate of the experimental group was 92.5%,which was significantly higher than that of the controlled group(72.5%,P<0.05).Compared with the controlled group,the relief time of all symptoms(persistent high fever,asthma,cough and sputum)in the experimental group was significantly shortened(P<0.05).Compared with before treatment,the CPIS score,APACHE II score and TCM syndrome score in the two groups were significantly decreased after treatment(P<0.05).Moreover,compared with the controlled group,the CPIS score,APACHE II score and TCM syndrome score of the experimental group decreased more significantly after treatment(P<0.05).Compared with before treatment,after treatment,the levels of CRP,TNF-αand IL-6 in 2 groups were significantly decreased(P<0.05),while the level of IgG was significantly increased(P<0.05).Compared with the controlled group,the levels of CRP,TNF-α,IL-6 and IgG in the experimental group were significantly decreased(P<0.05).Conclusion:The selection of Xuanbai Chengqi Decoction for the treatment of patients with severe pneumonia can achieve a significant clinical effect,not only can effectively inhibit the inflammatory response,so that the immune function of the body is significantly improved,but also can significantly improve the clinical symptoms and prognosis of patients,with clinical promotion value.