柴胡和胃化瘀汤对反复性消化性溃疡合并幽门螺旋杆菌感染患者血清VEGF及BFGF水平的影响分析

Effect of Chaihu Hewei Huayu Decoction on Serum VEGF and bFGF Levels in Patients with Recurrent Peptic Ulcer Complicated with Helicobacter Pylori Infection

目的:观察柴胡和胃化瘀汤对反复性消化性溃疡患者血清血管内皮细胞生长因子(VEgF)及碱性成纤维细胞生长因子(BFgF)水平的影响分析。方法:选取在广州中医药大学东莞医院(2018年5月—2021年5月时期)收治以反复性消化性溃疡合并幽门螺旋杆菌感染为诊断的患者总计60例,随机数字表法分成每组30例患者,其中1组以四联抗HP常规治疗,另1组在上述基础上联合柴胡和胃化瘀汤为研究组。比较两组患者在治疗前、后中医症状体征评分、血清VEgF及BFgF水平。结果:治疗后两组在症状积分与治疗前比较有明显的降低,研究组与对照组相比其水平更低,症状表现更轻微(P<0.05)。治疗后两组在血清VEgF及BFgF水平与治疗前比较有明显的升高,研究组与对照组相比其水平更高(P<0.05)。结论:在反复性消化性溃疡患者治疗中,以柴胡和胃化瘀汤治疗,可明显地降低患者的症状积分,改善血清VEgF及BFgF水平。

Objective:To observe the effect of Chaihu Hewei Huayu Decoction on the levels of serum vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in patients with recurrent peptic ulcer.Methods:a total of 60 patients with recurrent peptic ulcer complicated with Helicobacter pylori infection were selected from Dongguan Hospital of Guangzhou University of traditional Chinese medicine(from May 2018 to may 2021).They were randomly divided into 30 patients in each group.One group was treated with quadruple anti HP routine treatment,and the other group was treated with Chaihu and weihuayu Decoction on the basis of the above.The scores of TCM symptoms and signs,serum VEGF and bFGF levels were compared between the two groups before and after treatment.Results:after treatment,the symptom scores of the two groups were significantly lower than those before treatment.Compared with the control group,the level of the study group was lower and the symptoms were more mild(P<0.05).After treatment,the levels of serum VEGF and bFGF in the two groups were significantly higher than those before treatment,and the levels in the study group were higher than those in the control group(P<0.05).Conclusion:in the treatment of patients with recurrent peptic ulcer,Chaihu and weihuayu decoction can significantly reduce the symptom score and improve the levels of serum VEGF and bFGF.