间充质干细胞在再生障碍性贫血中的应用

Application of mesenchymal stem cells in aplastic anemia

间充质干细胞(mesenchymal stem cell, MSC)是一种多能干细胞,由Caplan及其同事于1991年首次提出。干细胞具有自我更新和自我分化的共同特性[1],MSC也不例外,既可以分化为骨、软骨、脂肪等中胚层组织,也可以分化为其他胚层组织。MSC不仅可以从骨髓中分离出来,也可从骨骼肌、骨外膜、骨小梁、脐带、脂肪组织、肺、月经、子宫内膜息肉中分离出,因此MSC的来源可多种多样,在临床上作用很广泛[2-4]。

Mesenchymal stem cell is different between aplastic anemia patients and the normal. Infusion of mesenchymal stem cell not only increases the success rate of hematopoietic stem cell implantation, but also reduces the severity of graft versus host disease. Therefore, mesenchymal stem cell in patients with aplastic anemia has good research background.