血小板捐献者外周血参数在血小板捐献前后的变化:1项倾向性匹配方法分析研究

How apheresis donation effects peripheral blood parameters in plateletpheresis donors:Propensity Score Matching method

目的分析研究血小板捐献者外周血参数在血小板捐献前后的变化情况。方法以在2019年8月1日~2020年7月31日于广州机采献血点的10444位献血者为研究对象,将初次献血者作为对照组,献血次数≥2次的献血者作为实验组。采用倾向性匹配方法匹配2组的年龄和性别后,t检验对比2组研究对象外周血参数变化的差异。结果捐献血小板后血小板计数增加(P<0.05);白细胞计数减少(P<0.05);血红蛋白减少(P<0.05);红细胞计数减少(P>0.05);红细胞比积不变(P>0.05)。结论本研究结果显示,在排除年龄、性别的影响外,捐献机采血小板后,血小板计数增加,白细胞计数和血红蛋白减少,红细胞和红细胞比积不变,但均在正常参考值范围内。

Objective To investigate the changes of platelet,white blood cell,red blood cell counts,Hb and PCV before and after plateletpheresis donation.Methods 10444 platelet donors who donated platelet from Aug 1,2019 to Jul 31,2020 were selected as subjects,among which first-time donors were selected as control group and donors who donated twice or more as donation group.After matching gender and age using Propensity Score Matching method in the two groups,the changes of platelet,white blood cell,red blood cell counts,Hb and PCV of platelet blood donors were compared by t test.Results There were a slight increase in Plt(t=-6.651,P<0.05),a decrease in WBC(t=2.312,P<0.05),a decrease in hemoglobin(t=4.643,P<0.05),and no change in RBC(t=1.439,P>0.05)and in PCV(t=0.030,P>0.05)after plateletpheresis donation.Conclusion Plateletpheresis donation has an effect on some peripheral blood parameters,but within the normal reference range.