药物不良反应的诊治成本及其分析框架探讨

Discussion on the Cost of Diagnosis and Treatment and Analysis Framework of Adverse Drug Reactions

回顾性综述药物不良反应(ADRs)的主要分类、发生频率、严重程度、可预防性和监测识别以及诊治成本等特征,指出获得ADRs诊治成本的研究难点以及缺乏系统性研究的现状,把握ADRs及其诊治成本是评价药物价值、指导临床用药和做出宏观卫生决策的必要基础。提出了开展系统性ADRs诊治成本研究的3种主要思路,并倡议在药物监测制度基础上,由政府、各类机构和研究者多方参与,建立统一的研究注册制度和标准化共享数据平台的设想。

To retrospectively review the main classification,frequency,severity,preventability,monitoring and identification,diagnosis and treatment costs and other characters of Adverse Drug Reactions(ADRs),and to point out the research difficulties in obtaining the diagnosis and treatment cost of ADRs and the current situation of the lack of systematic research.Grasping ADRs and the diagnosis and treatment cost is a necessary basis for evaluating the value of drugs,guiding clinical medication and making macro-health decisions.Three main ideas for carrying out systemic research on the cost of diagnosis and treatment of ADRs were proposed.An idea that on the basis of the drug monitoring system,the government,various institutions and researchers participate in multiply to establish a unified research registration system and a standardized shared data platform was also proposed.