加味四君子汤联合化疗在晚期直肠癌患者中的效果观察

Efficacy Observation of Sijunzi Tang Modified Combined with Chemotherapy on Late Rectal Cancer Patients

为观察加味四君子汤联合化疗在晚期直肠癌患者中的效果,将76例晚期直肠癌患者随机分为对照组和观察组,每组38例。对照组患者行常规化疗,观察组患者在对照组基础上再给予中药加味四君子汤治疗,观察2组患者治疗前后机体免疫状态和情绪的变化。结果显示,治疗前2组患者CD3+、CD4+、CD8+以及CD4+/CD8+值比较差异无统计学意义(P>0.05),治疗后观察组患者CD3+、CD4+以及CD4+/CD8+值高于对照组(P<0.05),CD8+值低于对照组(P<0.05),观察组患者的焦虑自评量表(SAS)、抑郁自评量表(SDS)评分均低于对照组(P<0.05)。结果表明,加味四君子汤联合化疗治疗可有效提高晚期直肠癌患者的免疫力,改善患者的负面情绪,效果满意。

This study was to observe the efficacy of Sijunzi Tang Modified(Tang,a TCM formula)combined with chemotherapy on late rectal cancer patients,76cases,were randomly divided into control group(38cases,received routine chemotherapy)and observation group(38cases,routine chemotherapy plus Tang);then,observed both groups'patients'immuno-situation and emotion change.As results,before treatment in the levels of CD3+,CD4+,CD8+,and CD4+/CD8+value there was no statistical difference between the two groups(P>0.05);after treatment in the levels of CD3+、CD4+and CD4+/CD8+value,as well as CD8+level observation group was respectively higher,as well as lower than control group(all,P<0.05);in the score ratings on SAS and SDS observation group was all lower than control group(all,P<0.05).Results show that Tang plus chemotherapy can effectively enhance patients'immunity,improve their negative emotion,which has satisfactory efficacy.