盐酸氨溴索与沙丁胺醇气雾剂联合治疗慢性支气管炎急性发作的临床效果

Clinical effect of ambroxol hydrochloride combined with salbutamol aerosol in the treatment of acute exacerbation of chronic bronchitis

目的探讨盐酸氨溴索与沙丁胺醇气雾剂联合治疗慢性支气管炎急性发作的临床效果。方法研究对象为2019年6月至2020年6月来我院治疗的慢性支气管炎急性发作患者81例,随机分组,对照组40例,观察组41例。两组患者均给予基础治疗,对照组在基础治疗上用沙丁胺醇治疗,观察组在对照组的基础上用盐酸氨溴索注射液治疗,比较临床疗效、动脉氧分压(PaO;)、动脉二氧化碳分压(PaCO;)、症状缓解时间。结果观察组总有效率为95.12%,高于对照组的75.00%,两组比较,差异有统计学意义(P<0.05)。治疗后观察组和对照组PaO;[(78.25±15.68)mmHg、(71.85±12.93)mmHg]高于治疗前[(66.38±10.72)mmHg、(66.12±10.47)mmHg],PaCO;[(40.67±6.15)mmHg、(47.34±7.81)mmHg]低于治疗前[(51.43±9.07)mmHg、(51.76±9.25)mmHg],差异有统计学意义(P<0.05);治疗后观察组PaO;高于对照组,PaCO;低于对照组,两组比较,差异有统计学意义(P<0.05)。治疗后观察组喘息缓解时间为(4.13±0.56)d、咳嗽缓解时间为(4.59±0.78)d、咳痰缓解时间为(3.20±0.47)d、肺部啰音缓解时间为(5.21±0.89)d,短于对照组的(5.63±0.97)d、(6.29±1.23)d、(5.92±1.16)d、(6.85±1.34)d,两组比较,差异有统计学意义(P<0.05)。结论盐酸氨溴索与沙丁胺醇气雾剂联合治疗慢性支气管炎急性发作效果显著,能够提高患者的肺功能,改善患者的血气分析指标,使整体治疗效果显著提升。

Objective To investigate the clinical effect of ambroxol hydrochloride combined with salbutamol aerosol in treating acute exacerbation of chronic bronchitis. Methods A total of 81 patients with acute exacerbation of chronic bronchitis treated in our hospital from June 2019 to June 2020 were randomly divided into the control group(40 cases)and the observation group(41 cases). Both groups were given basic treatment. The control group was treated with salbutamol on the basis of basic treatment, and the observation group was treated with ambroxol hydrochloride injection based on the control group. The clinical efficacy, PaO;, PaCO;, and symptom remission time were compared. Results The total effective rate of the observation group was 95.12%, which was higher than 75.00% of the control group, and the difference was statistically significant(P<0.05). After treatment, the PaO;[(78.25±15.68)mmHg,(71.85±12.93)mmHg]in the observation group and control group was higher than that before treatment [(66.38±10.72)mmHg,(66.12±10.47)mmHg],the PaCO;[(40.67±6.15)mmHg,(47.34±7.81)mmHg] was lower than that before treatment [(51.43±9.07)mmHg,(51.76±9.25)mmHg], and the difference was statistically significant(P<0.05). After treatment, the PaO;in the observation group was higher than that in the control group, PaCO;was lower than that in the control group, and the difference was statistically significant(P<0.05). After treatment, the wheezing relief time(4.13±0.56) d, cough relief time(4.59±0.78) d, expectoration relief time(3.20±0.47) d, and pulmonary rales remission time(5.21±0.89) d in the observation group were significantly shorter than those in the control group [(5.63 ±0.97)d,(6.29±1.23)d,(5.92±1.16)d,(6.85±1.34)d], and the difference was statistically significant(P<0.05). Conclusion Ambroxol hydrochloride combined with salbutamol aerosol in the treatment of acute exacerbation of chronic bronchitis has a significant effect, which can improve the pulmonary function of patients, improve the blood gas analysis index of patients, and significantly improve the overall therapeutic effect.