左炔诺孕酮宫内节育系统治疗子宫内膜增生症的效果探析

The Effect of Levonorgestrel Intrauterine Contraceptive System in the Treatment of Endometrial Hyperplasia

目的分析左炔诺孕酮宫内节育系统治疗子宫内膜增生症的效果及作用机制。方法选择本院2018年6月—2019年11月子宫内膜增生症患者共70例,根据随机数字表的方式将患者分组,每组35例,对照组以孕激素干预,研究组则予以左炔诺孕酮宫内节育系统。比较两组治疗前后患者子宫内膜厚、子宫腔体积、痛经程度、经量、血红蛋白水平、转归率、不良反应、复发率。结果研究组治疗后患者子宫内膜厚、子宫腔体积、痛经程度、经量低于对照组,血红蛋白水平高于对照组,转归率高于对照组,差异有统计学意义(P<0.05)。两组均无严重不良反应,差异无统计学意义(P> 0.05)。研究组的复发率低于对照组,差异有统计学意义(P <0.05)。结论左炔诺孕酮宫内节育系统对于子宫内膜增生症的治疗效果确切,可有效改善患者的月经情况,降低子宫内膜厚度和缩小子宫腔,安全性高,且可降低疾病的复发率。

Objective To analyze the effect and mechanism of levonorgestrel intrauterine birth control system in the treatment of endometrial hyperplasia. Methods A total of 70 patients with endometrial hyperplasia in our hospital from June 2018 to November 2019 were selected. The patients were divided into groups according to a random number table. Each group was 35 cases. The control group was treated with progesterone, and the study group was treated with left-handed progesterone. Norgestrel intrauterine birth control system. The endometrial thickness, uterine cavity volume, degree of dysmenorrhea, menstrual volume,hemoglobin level, outcome rate, adverse reaction, and recurrence rate were compared between the two groups before and after treatment. Results After treatment, the patients in the study group had lower endometrial thickness,uterine cavity volume, dysmenorrhea, and menstrual volume than the control group. The hemoglobin level was higher than that of the control group, and the outcome rate was higher than that of the control group. The difference was statistically significant(P<0.05). There were no serious adverse reactions in the two groups, and the difference was not statistically significant(P>0.05). The recurrence rate of the study group was lower than that of the control group, and the difference was statistically significant(P<0.05). Conclusion The levonorgestrel intrauterine contraceptive system has a definite therapeutic effect on endometrial hyperplasia. It can effectively improve the patient’s menstrual condition, reduce the thickness of the endometrium and shrink the uterine cavity, with high safety,and can reduce the recurrence rate of the disease.