参芪麦味地黄汤对2型糖尿病患者血液流变学及炎性因子水平的影响

Effect of Shenqi Maiwei Dihuang Decoction on Hemorheology and Inflammatory Factors in Type 2 Diabetes Patients

目的研究参芪麦味地黄汤对2型糖尿病患者血液流变学及炎性因子水平的影响。方法2018年6月—2020年1月,选取治疗的2型糖尿病患者112例,根据随机数字表法,将其进行分组,其中对照组56例,观察组56例。对照组患者给予格列吡嗪和二甲双胍治疗,观察组在对照组的基础上加用参芪麦味地黄汤治疗。9 d为一个疗程,2组均治疗4个疗程。对比2组患者治疗后的治疗总有效率、治疗前后血液流变学指标水平及血清TNF-α、CRP、IL-6水平变化。结果治疗后,观察组患者治疗总有效率92.86%,高于对照组的78.57%;2组患者血浆黏度、血小板聚集率、全血还原黏度及血清CRP、TNF-α、IL-6水平与治疗前相比均呈降低走向,且观察组与对照组相比呈降低走向(均P<0.05)。结论在格列吡嗪和二甲双胍治疗2型糖尿病基础上,联合参芪麦味地黄汤,可提高治疗总有效率,对血液流变学水平进行改善,使患者血清TNF-α、CRP、IL-6水平降低,机体炎症反应被抑制,从而促进病情恢复。

Objective To study the effects of Shenqi Maiwei Dihuang decoction on hemorheology and inflammatory factors in type 2 Diabetes patients.Methods From June 2018 to January 2020,112 cases were selected for treatment in our hospital,according to the random number table method,they were divided into groups,including 56 cases in the control group and 56 cases in the observation group.Patients in the control group were treated with glipizide and metformin,and the experimental group was treated with Shenqi Maiwei Dihuang decoction on the basis of the control group.9 days was a course of treatment,and both groups were treated for 4 courses.The total effective rate of the two groups of patients after treatment,changes of blood rheology indexes and serum TNF-α,CRP,IL-6 levels before and after treatment was compared.Results After treatment,the total effective rate of treatment in the observation group was 92.85%,which was higher than the78.57%in the control group.After treatment,the plasma viscosity,platelet aggregation rate,whole blood reduced viscosity,and serum TNF-α,CRP,and IL-6 levels of the two groups were all lower than before treatment,and the observation group was lower than the control group(all P<0.05).Conclusion Based on the treatment of type 2 diabetes with glipizide and metformin,the combination of Shenqi Maiwei Dihuang decoction can increase the total effective rate of treatment and improve the level of blood rheology,and reduce the patient’s serum TNF-α,CRP,IL-6 levels,and inhibit the body’s inflammatory response,thereby promoting recovery.