光动力疗法与LED红光联合石膏倒模治疗中重度痤疮的临床观察

Effectiveness of photodynamic therapy and LED red light combined with plaster casting on moderate and severe acne

目的探讨光动力疗法与LED红光联合石膏倒模治疗中重度痤疮的临床疗效。方法收集68例中重度痤疮患者的临床资料,根据治疗方法不同分为氨基酮戊酸光动力疗法(ALA-PDT)组、LED红光联合石膏倒模治疗组各34例,在治疗前及治疗后第2周、第4周、第6周、第12周随访时拍照、记录皮损数目、进行GAGS评分、记录不良反应。结果在治疗后同一时间点,ALA-PDT组与LED红光联合石膏倒模治疗组相比,ALA-PDT组有效率和疗效指数更高(P<0.05),第4周、第6周、第12周ALA-PDT组炎症性皮损数量显著减少(P<0.05),第12周ALA-PDT组非炎症性皮损数量显著减少及GAGS评分显著下降,而第2周、第4周、第6周两组非炎症性皮损数量及GAGS评分无显著性差异(P>0.05)。结论光动力疗法、LED红光联合石膏倒模治疗中重度痤疮均有效,而光动力疗法起效更快,对炎症性皮损的疗效更好。

Objective To investigate the effectiveness of photodynamic therapy(PDT) and LED red light combined with plaster casting on moderate and severe acne. Methods The clinical data of 68 patients with moderate and severe acne were collected. The patients were divided into ALA-PDT group and LED red light combined with plaster casting group depending on the different treatments, 34 cases in each group. Photographs were taken before treatment and at week 2, 4, 6, and 12 after treatment, the skin lesion counts, GAGS scores and adverse reactions were recorded. Results At the same time point after treatment, the effective rate and the efficacy indexes in ALA-PDT group were higher than those in LED red light combined with plaster casting group(P<0.05). The count of inflammatory skin lesions in ALA-PDT group was significantly decreased at week 4, week 6, and week 12(P<0.05), the count of non-inflammatory skin lesions and GAGS score in ALA-PDT group decreased significantly at week 12(P<0.05). There was no significant difference in the count of non-inflammatory skin lesions or GAGS score between the two groups at week 2, week 4, and week 6(P>0.05). Conclusions Both PDT and LED red light combined with plaster casting are effective on moderate and severe acne. PDT works faster and has better efficacy for inflammatory skin lesions.