铁超载在非酒精性脂肪性肝病中的作用

Role of iron overload in nonalcoholic fatty liver disease

铁超载与非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)关系紧密,肝脏铁超载可分为原发性及继发性病因两大类,常规采用血清铁蛋白及核磁共振成像来评估。铁作为肝脏损伤和肝病进展的重要因素,通过使肝脏处于氧化应激状态和增加胰岛素抵抗产生肝损伤,并对多种免疫细胞产生影响,促进NAFLD进展至肝纤维化。治疗以去铁疗法/抗氧化剂的应用为主。本文对铁超载与NAFLD的关系,铁超载参与NAFLD疾病进展的机制,以及NAFLD铁超载的治疗进行综述。

Iron overload is closely related to non-alcoholic fatty liver disease(NAFLD). Hepatic iron overload can be divided into primary and secondary causes. Serum ferritin and nuclear magnetic resonance imaging are routinely used to evaluate it. Iron, as an important factor in the progression of liver damage and liver disease, causes liver damage by putting the liver in a state of oxidative stress and increasing insulin resistance, and affects a variety of immune cells, thereby promoting the progression of NAFLD to liver fibrosis.Treatment is based on iron removal therapy/antioxidant application. In this article, we will summarize the relationship between iron overload and NAFLD, explain the mechanisms of iron overload involved in the progression of NAFLD disease, and summarize the treatment of iron overload in NAFLD.