不同运动方式改善肥胖/超重青少年胰岛素抵抗效果的meta分析

A Meta-Analysis of the Effects of Different Exercise Modes on Insulin Resistance in Obese/Overweight Adolescents

目的:从胰岛素水平和胰岛素抵抗指数(Homeostasis model assessment-IR,HOMA-IR)的角度比较不同运动方式对肥胖/超重青少年代谢疾病的改善作用。方法:在pubmed、Embase、web of science、Cochrane li-brary以及知网等数据库检索并搜集有关运动干预改善肥胖青少年代谢疾病的随机对照试验(randomized con-trol trial,RCT),对文献进行筛选和纳入,并对纳入文献进行质量评价,采用Revman以及stata软件进行分析。结果:运动能显著降低肥胖/超重青少年的胰岛素水平(WMD=-2.25、95%CI=-2.54~-1.95、P<0.00001)以及HOMA-IR指数(WMD=-0.73、95%CI=-0.83~-0.63,P<0.00001);混合运动与高强度间歇运动方式在降低肥胖/超重青少年的胰岛素水平以及HOMA-IR指数方面效果较好。结论:运动干预能有效降低肥胖青少年体内胰岛素水平及HOMA-IR指数;其混合运动在降低胰岛素水平和HOMA-IR指数方面效果显著。

The paper aims to compare the improvement effects of different exercise modes on metabolic diseases in obese/overweight adolescents from the perspective of insulin levels and Homeostasis Model Assessment-IR(HOMA-IR).Randomized control trial(RCTS)of exercise intervention to improve metabolic diseases in obese adolescents in Pubmed,Embase,Web of Science,Cochrane Library and CNKI databases were searched and col-lected.Literature was screened and included,and the quality of the included literature was evaluated.Revman and Stata softwares were used for analysis.The results showed that exercise significantly reduced the insulin lev-els of obese/overweight adolescents(WMD=-2.25,95%CI=-2.54~-1.95,P<0.00001)and HOMA-IR index(WMD=-0.73,95%CI=-0.83~-0.63,P<0.00001).The combined exercise and high-in-tensity interval exercise were more effective in reducing insulin levels and HOMA-IR index in obese/overweight adolescents.It is concluded that exercise intervention can effectively reduce the insulin levels and HOMA-IR in-dex in obese adolescents,and combined exercise has a significant effect on reducing insulin levels and HOMA-IR index.