AFP、CEA、CA724和AFU联合检测对原发性肝癌的诊断价值

CEA and AFU for the primary liver cancer

目的探究血清甲胎蛋白(AFP)、糖链抗原724(CA724)、癌胚抗原(CEA)和α-L-岩藻糖苷酶(AFU)联合检测对原发性肝癌临床诊断的价值。方法选取该院2019年12月至2020年12月收治的80例原发性肝癌患者作为观察组(A组),另选取80例肝硬化患者(B组)和同期80例健康体检者(C组)作为对照组,检测3组受试者血清AFP、CA724、CEA和AFU的水平,并比较单个指标检测与联合检测对原发性肝癌诊断的价值。结果A组血清AFP、CA724、CEA和AFU均高于B组和C组,差异有统计学意义(P<0.05),血清AFP、CA724、CEA和AFU联合检测诊断原发性肝癌的特异度与灵敏度分别为85.38%和95.21%,较单个指标检测高。结论血清AFP、CA724、CEA和AFU联合检测可提高对原发性肝癌诊断的敏感度与准确度,对于临床诊断具有一定的参考价值。

Objective To explore the clinical diagnostic value of joint test of alpha-fetoprotein(AFP),carbohydrate antigen 724(CA724),carcinoembryonic antigen(CEA)andα-L-fucosidase(AFU)for the primary liver cancer.Methods Selected 80 primary liver cancer patients from December 2019 to December 2020 in Shanghai traditional chinese medicine integrated hospital as observation group(group A).Another 80 patients with liver cirrhosis(group B)and 80 healthy persons(group C)were selected as control group.AFP,CA724,CEA and AFU were tested for the 3 groups.Then compared the clinical diagnostic value between single index test and joint test for the primary liver cancer.Results A had higher AFP,CA724,CEA and AFU than group B and group C,the difference is statistically significant(P<0.05).The specificity and sensitivity of primary liver cancer are 95.38%and 96.21%,which are all higher than single index test.Conclusion Joint test of AFP,CA724,CEA and AFU can improve the sensitivity and accuracy of the diagnosis of primary liver cancer,and has certain reference value for clinical diagnosis.