4种红细胞制剂治疗AIHA患者对网织红细胞、血红蛋白及胆红素的影响

Effects of 4 kinds of red blood cell preparations on reticulocytes,hemoglobin and bilirubin in patients with AIHA

目的分析4种红细胞制剂治疗自身免疫性溶血性贫血(AIHA)患者对网织红细胞、血红蛋白及胆红素的影响。方法选80例AIHA患者作为研究对象,按照治疗方式不同分为悬浮红细胞组(20例)、去白悬浮红细胞组(20例)、洗涤红细胞组(20例)、去白洗涤红细胞组(20例),共4组。治疗前后,比较4组实验室指标变化、疗效合及不良反应。结果4组治疗前及治疗后网织红细胞、血红蛋白、胆红素水平比较,差异均有统计学意义(P<0.05),且洗涤红细胞组及去白洗涤红细胞组与悬浮红细胞组及去白悬浮红细胞组网织红细胞、血红蛋白、胆红素水平比较,差异均有统计学意义(P<0.05),洗涤红细胞组与去白洗涤红细胞组网织红细胞、血红蛋白、胆红素水平比较,差异无统计学意义(P>0.05),悬浮红细胞组及去白悬浮红细胞组网织红细胞、血红蛋白、胆红素水平比较,差异无统计学意义(P>0.05);4组治疗效果比较,洗涤红细胞组及去白洗涤红细胞组均高于悬浮红细胞组及去白悬浮红细胞组,差异有统计学意义(P<0.05),前两组之间比较,差异无统计学意义(P>0.05),后两组之间比较,差异无统计学意义(P>0.05);不良反应总发生率比较,洗涤红细胞组及去白洗涤红细胞组均低于悬浮红细胞组及去白悬浮红细胞组,差异有统计学意义(P<0.05),前两组之间比较,差异无统计学意义(P>0.05),后两组之间比较,差异无统计学意义(P>0.05)。结论4种不同种类的红细胞制剂治疗自身免疫性溶血性贫血患者结果比较,洗涤红细胞及去白洗涤红细胞疗效更显著,能提升患者网织红细胞、血红蛋白水平,降低胆红素水平,且不良反应更少。

Objective To analyze the effects of four red blood cell preparations on reticulocytes,hemoglobin and bilirubin in AIHA patients.Methods Eighty patients with autoimmune hemolytic anemia were selected as the researc.Methods According to different treatment methods,they were divided into 4 groups:suspended red blood cell group(20 cases),whitened red blood cell group(20 cases),washed red blood cell group(20 cases)and whitened washed red blood cell group(20 cases)Before and after treatment,the changes of laboratory indexes,curative effects and adverse reactions were compared among the 4 groups.Results Four groups before and after treatment,reticulocyte hemoglobin,bilirubin level comparison,the differences were significantly(P<0.05),and washing to red blood cells and white washing group of red blood cells and suspended red blood cells and white suspended red blood cells to networking woven RBC,hemoglobin,bilirubin level comparison,the differences were significantly(P<0.05),washing RBC group to white washed red blood cells and networking woven RBC,hemoglobin,bilirubin level comparison,the differences were not significantly(P>0.05),suspended red blood cells and white suspended red blood cells to networking woven RBC,hemoglobin,bilirubin level comparison,the difference were not significant(P>0.05).The treatment effect of the four groups was higher in the washed red blood cell group and the whitened red blood cell group than in the suspended red blood cell group and the whitened suspended red blood cell group,the difference was significantly(P<0.05).The difference between the first two groups was not significant(P>0.05),and the difference between the last two groups was not significant(P>0.05).The total incidence of adverse reactions was lower in the washed red blood cell group and the bleached red blood cell group than in the suspended red blood cell group and the bleached red blood cell group,the difference was significantly(P<0.05).The difference between the first two groups was not significant(P>0.05),while the difference between the second two groups was not significant(P>0.05).Conclusion Compared with the results of 4 different types of red blood cell preparations in the treatment of patients with autoimmune hemolytic anemia,the efficacy of washing red blood cells and washing red blood cells without white is more significant,which can improve the level of reticulocyte and hemoglobin,reduce the level of bilirubin,and have fewer adverse reactions.