趋化因子CXCL13及其配体CXCR5与相关疾病的研究进展

Advances in chemokine CXCL13 and its ligand CXCR5 and related diseases

趋化因子是一类趋化粒细胞、单核细胞和巨噬细胞等炎症细胞定向迁移的细胞因子,它的功能由相应受体介导,两者不仅在炎性反应和过敏反应中发挥重要作用,亦参与肿瘤的生长、转移。笔者拟就CXCL13与肿瘤、结缔组织疾病、神经系统疾病等关系的最新研究进展进行阐述,旨在发现CXCL13在上述疾病发病机制中的具体作用,为临床采取新策略诊断及分子靶向治疗上述疾病提供参考。

Chemokines are a kind of cytokines that chemotactic granulocytes,monocytes,macrophages and other inflammatory cells migrate directionally.Their functions are mediated by corresponding receptors.They not only play an important role in inflammatory and allergic reactions,but also participate in the growth and metastasis of tumors.This paper reviews the latest research progress of CXCL13 in relation to tumors,connective tissue diseases and nervous system diseases,aiming to discover the specific role of CXCL13 in the pathogenesis of these diseases,and to provide references for clinical diagnosis and molecular targeted therapy of these diseases.