血清HMGB1、IL-6水平与结肠癌患者淋巴结转移的相关性

Correlation between Serum HMGB1,IL-6 Levels and Lymph Node Metastasis in Patients with Colon Cancer

目的:观察血清高迁移率族蛋白B1(HMGB1)、白细胞介素-6(IL-6)在结肠癌患者中的表达,并分析二者与患者淋巴结转移的关系。方法:回顾性分析,收集2018年2月~2021年2月某院收治的58例经病理证实发生淋巴结转移的结肠癌患者临床资料纳入转移组;另收集同期收治的58例未发生淋巴结转移的结肠癌患者临床资料纳入无转移组,查阅资料,比较两组基线资料及入院时血清HMGB1、IL-6水平,分析二者与结肠癌患者淋巴结转移的关系。结果:转移组入院时血清HMGB1、IL-6水平高于无转移组(P<0.05);组间其他资料对比,差异无统计学意义(P>0.05);经Logistic回归分析结果显示,入院时血清HMGB1、IL-6过表达与结肠癌患者淋巴结转移有关,可能是患者出现淋巴结转移的风险因子(OR>1(P<0.05));入院时血清HMGB1、IL-6单独及联合诊断结肠癌患者淋巴结转移的AUC分别为0.810、0826、0873,均有一定诊断价值,且血清HMGB1、IL-6分别取35.515ng·mL^(-1)、385.230 ng·mL^(-1)时,可获得最佳诊断效能。结论:血清HMGB1、IL-6水平可能与结肠癌患者淋巴结转移存在一定联系。

Objective:To observe the expression of serum high mobility group protein B1(HMGB1)and interleukin-6(IL-6)in patients with colon cancer,and to analyze the relationship between the two and lymph node metastasis.Methods:A retrospective analysis was performed.The clinical data of 58 patients with colon cancer and lymph node metastasis confirmed by pathology who were admitted to a hospital from February 2018 to February 2021 were collected and included in the metastasis group.The clinical data of 58 patients with metastatic colon cancer patients without lymph node metastasis admitted to a hospital during the same period were collected and included in the non-metastasis group.The baseline data of the two groups and the serum HMGB1 and IL-6 levels at admission were compared to analyze the relationship between the two indexes and lymph node metastasis in patients with colon cancer.Results:The levels of serum HMGB1 and IL-6 at admission in the metastasis group were higher than those in the non-metastasis group(P<0.05).There was no significant difference in other data between the two groups(P>0.05).The logistic regression analysis showed that the overexpression of serum HMGB1 and IL-6 at admission was related to lymph node metastasis in patients with colon cancer,and may be a risk factor for lymph node metastasis in patients(OR>1,P<0.05).The AUC of serum HMGB1 and IL-6 alone and combined in the diagnosis of lymph node metastasis in patients with colon cancer at admission was 0.810,0.826,and 0.873,respectively,all of which were of certain diagnostic value.The best diagnostic performance was obtained when the serum HMGB1 and IL-6 were 35.515ng·mL^(-1) and 385.230ng·mL^(-1),respectively.Conclusion:Serum HMGB1 and IL-6 levels may be related to lymph node metastasis in patients with colon cancer.