硫酸镁联合硫酸特布他林雾化吸入对毛细支气管炎患儿血清炎性因子水平的影响

Effect of Magnesium Sulfate Combined with Terbutaline Sulfate Atomization Inhalation on the Levels of Serum Inflammatory Factors in Children with Bronchiolitis

目的:探究硫酸镁联合硫酸特布他林雾化吸入对毛细支气管炎患儿血清炎性因子水平的影响。方法:选择2019年5月~2020年12月某院收治的毛细支气管炎患儿102例,按随机数字表法分为对照组和观察组各51例,对照组给予硫酸特布他林雾化吸入用溶液,观察组在此基础上加用硫酸镁。比较两组治疗效果、血清炎性因子水平、肺功能及安全性。结果:与对照组相比,观察组治疗总有效率较高,有统计学差异(P<0.05);两组治疗前血清炎性因子水平、肺功能比较,无统计学差异(P>0.05);与对照组相比,观察组治疗后白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、总免疫球蛋白IgE(TIgE)、降钙素原(PCT)、C-反应蛋白(CRP)、功能残余量(FRC)、呼吸频率(RR)及有效呼吸道阻力(Reff)水平均较低,VT水平较高,有统计学差异(P<0.05)。观察组不良反应发生率为13.73%,略高于对照组的5.88%,差异无统计学意义(P>0.05)。结论:硫酸镁联合硫酸特布他林雾化吸入能够减轻毛细支气管炎患儿炎症反应,改善肺功能,具有一定安全性,值得临床推广应用。

Objective:To explore the effect of magnesium sulfate combined with terbutaline sulfate atomization inhalation on the levels of serum inflammatory factors in children with bronchiolitis.Methods:A total of 102 children with bronchiolitis admitted to a hospital from May 2019 to December 2020 were selected and divided into two groups according to the random number table method,with 51 cases in each group.The control group was given terbutaline sulfate atomization inhalation solution,and on this basis,the observation group was given magnesium sulfate.The treatment effect,serum inflammatory factor levels,lung function and safety were compared between the two groups.Results:Compared with the control group,the total effective rate of treatment in the observation group was higher,with statistical difference(P<0.05).There was no statistical difference in the serum inflammatory factor levels and lung function(P>0.05).Compared with the control group,the interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),total immunoglobulin IgE(TIgE),procalcitonin(PCT),C-reactive protein(CRP),functional residual capacity(FRC),respiratory frequency(RR)and effective airway resistance(Reff)levels in the observation group after treatment were lower,and VT levels were higher,with statistical difference(P<0.05).The incidence of adverse reactions in the observation group was 13.73%,which was slightly higher than 5.88%in the control group,and the difference was not statistically significant(P>0.05).Conclusion:Magnesium sulfate combined with terbutaline sulfate atomization inhalation can reduce the inflammatory response and improve lung function in children with bronchiolitis.It has certain safety and is worthy of clinical promotion and application.