摘要
阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是以呼吸暂停、低通气、血氧饱和度下降及睡眠结构紊乱为特征的一种疾病,是心血管疾病的严重危险因素。近年来研究发现,OSAHS患者合并高血压、冠状动脉粥样硬化性心脏病、胰岛素抵抗、2型糖尿病、代谢综合征、非酒精性脂肪肝等疾病的发病率增加。诸多研究显示,OSAHS患者常存在明显的糖脂代谢紊乱,并在心血管疾病的发病率、死亡率中扮演着重要角色。因此,本文从OSAHS与糖脂代谢的关系入手,从病因学层面,就OSAHS引起糖脂代谢紊乱及胰岛素抵抗的机制作一综述,以期为临床治疗提供新的思路。
Obstructive sleep apnea-hypopnea syndrome(OSAHS)is a disease marked by apnea,hypopnea,decreased oxygen saturation,and disordered sleep structure,which is a major risk for cardiovascular disease.Recent studies have found that OSAHS patients have an increased risk of hypertension,coronary atherosclerotic heart disease,insulin resistance,type 2 diabetes,metabolic syndrome,non-alcoholic fatty liver disease,etc.And these patients have a high prevalence of obvious glucolipid metabolism disorder(GMD),which plays an important role in cardiovascular morbidity and mortality in OSAHS.We reviewed the latest advances in the association of GMD and OSAHS,and the potential pathogenesis of OSAHSinduced GMD and insulin resistance,aiming at providing new ideas for clinical treatment of GMD in OSAHS.
作者
王云
何燕
刘师节
甘露路
高慧芳
梁敏
左志恒
杨莉
WANG Yun;HE Yan;LIU Shijie;GAN Lulu;GAO Huifang;LIANG Min;ZUO Zhiheng;YANG Li(Yan'an Hospital Affiliated to Kunming Medical University,Kunming 650051,China)
出处
《中国全科医学》
CAS
北大核心
2022年第2期243-247,共5页
Chinese General Practice
基金
云南省重大科技专项计划项目(2017ZF027)
云南省科技厅-昆医联合专项重点项目(2017FE468(-008))
云南省重大科技专项计划项目(2017ZF024-12)。