血清PCT、SAA及IL-6联合检测对肝硬化腹水合并腹腔感染的诊断和预后评估价值

Values of Combined Detection of Serum PCT,SAA and IL-6 in Diagnosis and Prognostic Evaluation of Patients with Liver Cirrhosis Ascites Associated by Abdominal Infection

目的分析血清降钙素原(PCT)、淀粉样蛋白A(SAA)及白细胞介素-6(IL-6)联合检测对肝硬化腹水合并腹腔感染的诊断和预后评估价值。方法选取2018年4月—2020年12月收治的85例肝硬化腹水为研究对象,根据是否合并腹腔感染分为观察组(合并腹腔感染)40例和对照组(未合并腹腔感染)45例;并随访观察组预后情况,根据预后分为好转组25例和恶化组15例。检测研究对象血清PCT、SAA及IL-6水平,并采用受试者工作特征(ROC)曲线分析三者对肝硬化腹水合并腹腔感染的诊断和预后评估价值。结果观察组血清PCT、SAA、IL-6水平高于对照组(P<0.01);好转组血清PCT、SAA、IL-6水平低于恶化组(P<0.05)。三者联合对肝硬化腹水合并腹腔感染诊断和预后评估的曲线下面积高于血清PCT、SAA、IL-6单独检测(P<0.05)。结论血清PCT、SAA及IL-6联合检测对肝硬化腹水合并腹腔感染诊断及预后评估的价值较高,能够为临床判断病情和制定合理治疗方案提供参考。

Objective To analyze the values of combined detection of serum procalcitonin(PCT),serum amyloid A(SAA)and interleukin-6(IL-6)in diagnosis and prognostic evaluation of patients with liver cirrhosis ascites associated by abdominal infection.Methods A total of 85 patients with liver cirrhosis ascites admitted between April 2018 and December 2020 were selected as research subjects.According to the presence or absence of abdominal infection,the patients were divided into observation group(n=40,having abdominal infection)and control group(n=45,without abdominal infection).Follow-up was conducted to observe prognoses in observation group,and,the patients in observation group were divided into improvement subgroup(n=25)and deterioration subgroup(n=15)according to prognoses.Serum levels of PCT,SAA and IL-6 in all subjects were detected,and their values in diagnosis and prognostic evaluation of liver cirrhosis ascites associated by abdominal infection were analyzed by using receiver operating characteristic(ROC)curve.Results Serum levels of PCT,SAA,and IL-6 in observation group were significantly higher than those in control group(P<0.05).Serum levels of PCT,SAA and IL-6 in improvement subgroup were significantly lower than those in deterioration subgroup(P<0.05).The area under ROC(AUC)of combined detection of the three indexes in diagnosis and prognostic evaluation of patients with liver cirrhosis ascites associated by abdominal infection was larger than those by PCT,SAA and IL-6 alone(P<0.05).Conclusion The combined detection of serum PCT,SAA and IL-6 is of good value in diagnosis and prognostic evaluation of patients with liver cirrhosis ascites associated by abdominal infection,which may provide reference for clinical diagnosis and development of treatment plan.