中药复方专利治疗高脂血症的用药规律分析

Analysis of the Rules of Using Traditional Chinese Medicine Compound Patents in the Treatment of Hyperlipidemia

目的通过分析中药治疗高脂血症的专利状况,研究中药治疗高脂血症的用药配伍规律。方法检索2000年1月—2020年7月国家专利数据库中治疗高脂血症的中药复方专利,录入EXCEL 2010建立数据库,运用SPSS 19.0采用频数分析、聚类分析、因子分析等技术研究中药复方的用药规律。结果共检索到治疗高脂血症的241项中药复方专利;中药频次结果显示共得到≥20次的高频中药30种,使用频率最多的药物为山楂,高频药物性味以温性、寒性和甘味、苦味为主,在归经方面排名前三的分别是肝经、脾经、胃经;基于聚类分析得到药物组合7类,因子分析共提取出10个公因子。结论本研究揭示了治疗高脂血症的中药复方专利的核心用药和方剂用药规律,对临床合理用药和新药的开发有一定的参考价值。

Objective By analyzing the patent status of traditional Chinese medicine for the treatment of hyperlipidemia,it is aimed to study the compatibility of traditional Chinese medicine for the treatment of hyperlipidemia.Methods Search for the patents of Chinese medicine compound prescriptions for the treatment of hyperlipidemia in the national patent database from January 2000 to July 2020,enter it into EXCEL 2010 to establish a database,and use SPSS 19.0 to use frequency analysis,cluster analysis,factor analysis and other techniques to study the use of Chinese medicine compound prescriptions law.Results A total of 241 Chinese medicine compound patents for the treatment of hyperlipidemia were retrieved;the frequency results of Chinese medicine showed that a total of 30 high-frequency Chinese medicines were obtained≥20 times,and the most frequently used medicine was hawthorn.The nature and taste of high-frequency medicine were mild and cold.Mainly sweet and bitter,the top three in terms of return are the liver meridian,spleen meridian,and stomach meridian.Based on cluster analysis,7 types of drug combinations are obtained,and a total of 10 common factors are extracted by factor analysis.Conclusion The study reveals the core medication and prescription medication rules of the patented traditional Chinese medicine compound for the treatment of hyperlipidemia,and has certain reference value for the development of clinical rational medication and new drugs.