风湿性多肌痛的发病机制

Pathogenesis of polymyalgia rheumatica

风湿性多肌痛(polymyalgia rheumatica,PMR)是仅次于类风湿关节炎(rheumatoid arthritis,RA)的第二大老年炎症性风湿病,以肩部、颈部及骨盆带疼痛和晨僵为主要特征。PMR发病机制复杂,目前尚未完全明确。近年来学者们发现感染、遗传、免疫及炎症等因素与PMR发病密切相关,在特定遗传背景下,感染触发炎症反应,导致相关免疫系统的激活或是PMR发病的重要机制。本文就目前PMR发病机制的研究进展做一综述,以提高对该疾病的认识。

Polymyalgia rheumatica(PMR)is most common inflammatory rheumatic disease of the elderly second only to rheumatoid arthritis(RA).It is characterized by proximal pain and stiffness in the shoulders,neck,and/or pelvic girdle.The pathogenesis of PMR is complex and has not been fully understood.In recent years,certain factors such as infection,genetic,immunization,and inflammation have been found to be closely associated with PMR.With particular genetic background,inflammatory response triggered by infection leading to immune system activation may cause PMR onset.This article summarizes the current research progress in the pathogenesis of PMR.