摘要
目的探讨雌激素受体阳性乳腺癌患者孕激素受体(PR)对体质量指数与预后关系的影响。方法收集2012年3月至2018年1月山西白求恩医院住院的病理证实为浸润性导管癌患者1 036例。以体质量指数(BMI)24 kg/m^(2)为分界值,将患者分为BMI≥24 kg/m^(2)组(608例)和BMI<24 kg/m^(2)组(428例)。采用免疫组织化学法检测肿瘤PR状态。比较BMI不同水平组间临床病理特征的差异;采用Kaplan-Meier法绘制全组和PR分层患者中BMI不同水平两组的总生存(OS)曲线,并行log-rank检验。采用单因素和多因素Cox比例风险模型分析影响OS的因素。结果中位随访4.0年(2.3~5.7年)。BMI <24 kg/m^(2)组和BMI≥24 kg/m^(2)组间年龄、组织学分级、分期、月经状态、肿瘤家族史不同,差异有统计学意义(均P<0.05)。全组中,BMI <24 kg/m^(2)组OS优于BMI≥24 kg/m^(2)组(P=0.033);在PR阴性的ER阳性乳腺癌患者中,BMI <24 kg/m^(2)组OS优于BMI≥24组(P=0.007);PR阳性的ER阳性乳腺癌患者中,BMI <24 kg/m^(2)组和BMI≥24 kg/m^(2)组间OS差异无统计学意义(P=0.466)。单因素Cox回归分析显示,BMI、PR、分期、月经状态与ER阳性乳腺癌患者OS相关(均P<0.05);多因素Cox回归分析显示,BMI≥24 kg/m^(2)(HR=1.916,95%CI:1.167~3.144,P=0.010)、PR阴性(HR=0.348,95%CI:0.208~0.583,P<0.001)为ER阳性乳腺癌患者OS的独立危险因素。结论与PR阳性、ER阳性肥胖乳腺癌患者相比,PR阴性、ER阳性患者生存率更低,因此,PR状态与ER阳性肥胖乳腺癌患者预后相关,为乳腺癌预防和诊治提供理论依据。
Objective This study aims to explore whether the association between body mass index(BMI and prognosis of estrogen receptor positive(ER+)breast cancer(BC)varies according to the tumor PR status.Methods We collected a total of 1 036 cases with invasive ductal breast cancer from March 2012 to January 2018 in department of breast surgery of Shanxi Bethune Hospital. Women were stratified according to their BMI(< 24,≥ 24 kg/m^(2)). Tumor PR status(PR-,PR+)was evaluated by immunohistochemistry. The differences of clinicopathological features between the groups with different BMI levels were compared;Kaplan-Meier method was used to draw the overall survival(OS)curve of the whole group and the patients stratified by PR with different BMI levels,and log-rank test was performed. Univariate and multivariate Cox proportional hazards models were used to analyze the factors affecting OS. Results The median follow-up period was 4.0 years(2.3 ~ 5.7 years). There were significant differences in age,histological grade,stage,menstrual status and family history of tumor between BMI < 24 kg/m^(2) group and BMI ≥ 24 kg/m^(2) group(P < 0.05). In the whole group,OS in BMI <24 kg/m^(2) group was better than that in BMI ≥ 24 kg/m^(2) group(P = 0.033). In breast cancer patients with PR-and ER+,OS in BMI < 24 kg/m^(2) group was better than that in BMI ≥ 24 kg/m^(2)(P = 0.007);In breast cancer patients with PR+and ER+,there was no significant difference in OS between BMI < 24 kg/m^(2) group and BMI ≥ 24 kg/m^(2) group(P =0.466). Univariate Cox regression analysis showed that BMI,PR,stage and menstrual status were associated with OS in ER positive breast cancer patients(P < 0.05). Multivariate Cox regression analysis showed that BMI ≥ 24 kg/m^(2)(HR = 1.916,95% CI:1.167 ~ 3.144,P = 0.010)and PR negative(HR = 0.348,95% CI:0.208 ~ 0.583,P < 0.001)were independent risk factors for OS in ER positive breast cancer patients. Conclusion Compared with PR+,ER+obese breast cancer patients,PR-,ER+women had poorer survival. It suggests that poorer survival is associated with high BMI among women diagnosed with ER+BC,which provides reference for the prevention and treatment of breast cancer.
作者
马利军
邢君
刘爱兰
高晋南
MA Lijun;XING Jun;LIU Ailan;GAO Jinnan(Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,the Third Hospital of Shanxi Medical University,Taiyuan 030032,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2021年第22期2877-2881,共5页
The Journal of Practical Medicine
基金
山西省卫生健康委员会基金(编号:2019008)。
关键词
乳腺肿瘤
体质量指数
孕激素受体
预后
breast tumor
body mass index
progesterone receptor
prognosis