提高喷雾干燥粒子肺部沉积的粒子工程策略

Particle engineering strategies for improving lung deposition of spray-dried particles

综述喷雾干燥的原理;粒子组分重分布、固化及固化后形态的改变等形成过程;喷雾干燥工艺对粒子性质的影响;空气动力学直径、密度、表面疏水处理等提高干粉吸入剂肺部沉积的粒子工程策略。认为喷雾干燥在肺部给药方面的主要优势是通过操纵和控制各种参数实现对颗粒特性的优化;结合粒子工程技术与合适的赋形剂,可以获得理想的喷雾干燥颗粒,使其最大限度地沉积在肺部靶向部位;通过优化颗粒空气动力学直径、降低颗粒密度以及对微粒进行表面疏水处理可以弥补喷雾干燥微粒在粉末流动性、分散性以及药物稳定性等方面的缺点。

The principle of spray drying,the formation process of particle composition redistribution,solidification and morphology change after solidification,effect of spray drying process on particle properties,and the particle engineering strategies to improve lung deposition of dry powder inhalations,such as aerodynamic diameter,density andsurface hydrophobic treatment were reviewed.It is considered that the main advantage of spray drying in pulmonary drug delivery is to optimize particle properties by manipulating and controlling various parameters,and combined with particle engineering technology and appropriate excipients,ideal spray drying particles can be obtained to maximize the deposition in the lung target site.Optimization of particle aerodynamic diameter,reduction of particle density and surface hydrophobic treatment of particles can make up the disadvantages of spray drying particles in powder fluidity,dispersion and drug stability.