铁盐催化的高选择性合成2-取代的吡啶并[2,3-b]吲哚衍生物

Highly Selective Synthesis of 2-Substituted Pyrido[2,3-b]indole Derivatives Catalyzed by Iron Salts

多环稠合的芳香含氮杂环化合物是一类非常重要的含氮杂环化合物,在药物和材料中得到了广泛的应用,而吡啶并吲哚类化合物是其重要的一类.目前,这类化合物的合成方法并不是很多,基于之前的工作基础,发展了一个在三氟甲磺酸铁作为催化剂条件下,利用邻氨基苯乙腈衍生物和3-二甲胺基烯胺酮类化合物作为反应原料,在温和的反应条件下,高效地选择性构建2-取代的吡啶并[2,3-b]吲哚结构的方法.

Polycyclic aromatic nitrogen-containing heterocyclic compounds are an important class of nitrogen-containing heterocyclic compounds,which have been widely used in drugs and materials,and indole-fused pyridine compounds are one of them.At present,the methods for the synthesis of these compounds were less reported.Based on previous work,a new route to 2-substituted pyrido[2,3-b]indole derivatives was developed,which employed 2-(2-aminophenyl)acetonitrile derivatives and N,N-dimethyl enaminones as the reaction substrates.The reaction provided the desired product with high selectivity and efficiency.