阴道微生物组:种群特征与疾病干预治疗

Vaginal microbiome:community characteristics and disease intervention

高通量测序技术的发展显著加快了对人类微生物组的理解。将人体微生物组与疾病关联,力求阐明疾病的发生进程,是推进个性化精准医疗的重要研究方向。近年来,栖居于女性阴道的微生物菌群日益受到关注,发现其生态失调与疾病发生、演变密不可分。文中综述了阴道微生物组与生殖道疾病发生、进展和治疗的最新进展,同时对阴道微生物组培养组、益生菌工程化改造以及合成菌群在阴道微生物组学研究以及疾病干预与治疗方面的前景进行了展望。

The application of high-throughput sequencing technologies has greatly enhanced our understanding to the human microbiome.The causal relations between human microbiome and diseases have become a critical issue to elucidate disease development and develop precision medicine.Recently,the study about vaginal microbiome(the microbial flora that inhabits the female vagina)has received wide interests.It has been shown that dysbiosis of vaginal microbiome was closely related to the development of genital tract diseases.This article summarizes the interaction between vaginal microbiome and disease and the treatment for the dysbiosis of vaginal microbiome.The culturomics of virginal microbiome,engineered probiotics and synthetic microbiome were also proposed.