Kunitz型丝氨酸蛋白酶抑制剂研究进展

Advances of Kunitz-type serine protease inhibitors

Kunitz型丝氨酸蛋白酶抑制剂是一类普遍存在的蛋白酶抑制剂,在体内各项生命活动中扮演着重要角色。这类抑制剂结构稳定且富有特色,通常具有一个或几个串联存在的Kunitz结构域,能够以类似底物的方式与丝氨酸蛋白酶结合,从而抑制酶的活性。在功能方面,Kunitz型丝氨酸蛋白酶抑制剂参与凝血和纤维蛋白溶解、肿瘤免疫、炎症调节以及抵抗细菌、真菌感染等过程。文中就Kunitz型丝氨酸蛋白酶抑制剂研究进展作一综述,为新型Kunitz型丝氨酸蛋白酶抑制剂的开发提供研究思路。

Kunitz-type serine protease inhibitors are a class of ubiquitous protease inhibitors,which play important roles in various life activities.The structures of such inhibitors are generally stable,and are usua lly characterized by the presence of one or several Kunitz domains in tandem,which are able to bind to serine proteases in a manner similar to substrate binding,thereby inhibiting enzyme activity.In terms of function,Kunitz-type serine protease inhibitors are involved in processes such as blood coagulation and fibrinolysis,tumor immunity,inflammation regulation,and resistance to bacterial and fungal infections.This article summarizes the advances of Kunitz-type serine protease inhibitors and provides new ideas for the development of novel Kunitz-type serine protease inhibitors.