人参皂苷CK新型给药系统研究进展

Research Progress in New Drug Delivery Systems of Ginsenoside CK

人参皂苷Compound K(CK)为人参二醇型皂苷经肠道菌群转化得到的产物,具有多种药理活性。但由于人参皂苷CK的口服生物利用度低限制了应用,因此开发新型给药系统来提高药物的生物利用度已成为当前研究的热点。本文将通过文献检索对国内外人参皂苷CK新型给药系统研究进展进行综述,以期为开发安全、有效的人参皂苷CK新制剂提供理论依据。

Ginsenoside compound K(CK) is a product obtained from the transformation of panaxadiol-type saponins by intestinal flora, and has a variety of pharmacological activities. However, low oral bioavailability of ginsenoside CK limits its application, therefore, developing new drug delivery systems to improve the bioavailability has become a hot topic in the current research. In this paper, the research advances in novel administration systems of ginsenoside CK at home and abroad were reviewed through literature retrieval in order to provide theoretical basis for the development of a safe and effective new preparation of ginsenoside CK.