周细胞在新生血管性眼病中的作用研究进展

Research progress on the role of pericytes in neovascular eye diseases

新生血管性眼病以病理性新生血管形成为病理特征,是威胁眼健康的主要疾病。近年来,各种新生血管性眼病发病率逐年提高,已成为严重的公共卫生问题,引起了广泛关注。病理性新生血管是多种细胞成分、多种病理因素互相包含、交互影响下形成的,单独干预其中一种因素往往很难达到理想治疗效果,因此需要更深入地研究新生血管的病理过程,探究新的调控新生血管的因子,以发现更有效的治疗方法。近年来研究发现,周细胞在多种新生血管性眼病的发生发展中起重要作用,针对周细胞采取干预措施将影响这些疾病的病理过程。本文将对新生血管性眼病中周细胞的具体作用以及调控周细胞的因素作出综述,为新生血管性眼病的治疗提供新的思路和方向。

Neovascular eye disease,which is characterized by pathological neovascular formation,is a major disease threatening visual health.In recent years,neovascular eye disease has become a serious public health problem and attracted widespread attention,with the incidence increasing year by year.Pathological neovascularization is formed under the mutual inclusion and interaction of a variety of cellular components and pathological factors.It is often difficult to achieve ideal therapeutic effect if we intervene only one of the factors.Therefore,it is in an urgent need to conduct a more in-depth study in the pathological process of neovascularization and explore new factors that regulate neovascularization in order to find more effective treatments of neovascular eye diseases.In recent years,pericyte has been proved to play important roles in the occurrence and development of various neovascular eye diseases and interventions for pericytes will affect the pathological process of these diseases.This article will review the specific roles of pericytes in some common neovascular eye diseases and the factors regulating pericytes in these diseases,which would provide new ideas in the treatment of neovascular eye diseases.