桉柠蒎肠溶软胶囊治疗分泌性中耳炎的效果及对耳积液IL-8、IL-10、IL-1β水平的影响

Efficacy of Eucalyptol,Limonene and Pinene Enteric Soft Capsules in the Treatment of Secretory Otitis Media and Its Influence on the Levels of IL-8,IL-10,IL-1βin Ear Effusion

目的:分析桉柠蒎肠溶软胶囊治疗分泌性中耳炎(SOM)的效果及对耳积液白细胞介素-8(IL-8)、IL-10、IL-1β水平的影响。方法:选取2018年1月-2020年1月本院收治的84例SOM患者,采用随机数字表法将其分为对照组和观察组,各42例(耳)。对照组给予鼓膜穿刺术后鼓室注射地塞米松治疗,观察组在对照组基础上加用桉柠蒎肠溶软胶囊治疗。比较两组鼓室导抗图类型、不同语言频率纯音听阈水平、疗效及耳积液IL-8、IL-10、IL-1β水平。结果:治疗后,观察组A型鼓室导抗图占比73.81%,高于对照组的45.24%(P<0.05)。观察组语言频率(500、1000、2000 Hz)的纯音听阈值均优于对照组(P<0.05)。观察组总有效率88.10%,高于对照组的69.05%(P<0.05)。治疗后,观察组耳积液IL-8、IL-10、IL-1β水平均低于对照组(P<0.05)。结论:桉柠蒎肠溶软胶囊可提升SOM治疗效果,改善中耳功能与听力水平,降低耳积液IL-8、IL-10、IL-1β水平。

Objective:To analyze the effect of Eucalyptol,Limonene and Pinene Enteric Soft Capsules in the treatment of secretory otitis media(SOM)and its influence on the levels of interleukin-8(IL-8),IL-10 and IL-1βin ear effusion.Method:A total of 84 patients with SOM admitted to our hospital from January 2018 to January 2020 were selected and divided into control group and observation group with 42 cases(ears)by random number table method.The control group was given Dexamethasone injection to the tympanum after tympanic membrane puncture,and the observation group was given Eucalyptol,Limonene and Pinene Enteric Soft Capsules on the basis of the control group.The type of tympanic impedance diagram,the pure tone hearing threshold level of different language frequencies,the curative effect and the level of IL-8,IL-10,and IL-1βin ear effusion were compared.Result:After treatment,the proportion of type A tympanogram in the observation group was 73.81%,which was higher than 45.24%in the control group(P<0.05).The pure tone hearing threshold of language frequencies(500,1000,2000 Hz)in the observation group were better than those of the control group(P<0.05).The total effective rate of the observation group was 88.10%,which was higher than 69.05%of the control group(P<0.05).After treatment,the levels of IL-8,IL-10 and IL-1βof ear effusion in the observation group were lower than those of the control group(P<0.05).Conclusion:Eucalyptol,Limonene and Pinene Enteric Soft Capsules can enhance the therapeutic effect of SOM,improve middle ear function and hearing,reduce the levels of IL-8,IL-10 and IL-1βin ear effusion.