复发性流产患者PAI-1、TSP-1、D-D水平变化及其临床意义

Changes and clinical significance of PAI-1,TSP-1 and D-D levels in patients with recurrent spontaneous abortion

目的观察复发性流产(RSA)患者纤溶酶原活化物抑制因子(PAI-1)、血小板反应蛋白-1(TSP-1)、交联纤维蛋白降解产物(D-D)水平变化及其临床意义。方法选取2018年1月至2019年3月本院收治的184例复发性流产患者作为RSA组,根据流产次数分为RSA1组(流产次数>3次)和RSA2组(流产次数≤3次),根据胎儿预后情况分为流产组和活产组。选取同时期具有正常分娩史、染色体、内分泌等检查均为正常且本次妊娠正常女性172例作为正常妊娠组,检测各组血清PAI-1、TSP-1、D-D水平,采用Pearson对RSA组血清PAI-1、TSP-1、D-D水平进行相关性分析,记录RSA组妊娠结局。结果 RSA组血清PAI-1、D-D、TSP-1含量显著高于正常妊娠组,差异均有统计学意义(P<0.05)。RSA组血清PAI-1与TSP-1表达水平无显著相关性(P>0.05),PAI-1与D-D表达水平无显著相关性(P>0.05),TSP-1与D-D表达水平无显著相关性(P>0.05)。流产组血清PAI-1、TSP-1、D-D水平显著高于活产组,差异均有统计学意义(P<0.05)。RSA1组PAI-1、TSP-1、D-D水平显著高于RSA2组,差异均有统计学意义(P<0.05)。结论 RSA患者血清PAI-1、TSP-1、D-D水平呈高表达,对RSA妊娠结局具有一定的临床应用价值。

Objective To observe the changes and clinical significance of plasminogen activator inhibitor-1(PAI-1),platelet reactive protein-1(TSP-1)and cross-linked fibrin degradation product(D-D)in patients with recurrent spontaneous abortion(RSA). Methods A total of 184 patients with RSA admitted to the hospital from January 2018 to March 2019 were selected in the RSA group. According to the frequency of abortion,they were divided into the RSA1 group(frequency of abortion more than 3 times)and the RSA2 group(frequency of abortion of or less than 3 times). 172 women with history of normal pregnancy and having normal pregnancy during the same period were selected as the normal pregnancy group. The serum levels of PAI-1,TSP-1 and D-D were measured. Pearson correlation analysis was performed to analyze the serum levels of PAI-1,TSP-1 and D-D in patients with RSA. Pregnancy outcomes of the RSA group were recorded.Results The levels of serum PAI-1,D-D and TSP-1 in the RSA group were significantly higher than those in the normal pregnancy group(P<0.05). There was no significant correlation between serum PAI-1 and TSP-1 levels,PAI-1 and D-D levels orTSP-1 and D-D levels(P>0.05). The levels of serum PAI-1,TSP-1 and D-D in the abortion group were significantly higher than those in the live birth group,and the differences were statistically significant(P<0.05). The levels of PAI-1,TSP-1 and D-D in the RSA1 group were significantly higher than those in the RSA2 group,and the differences were statistically significant(P<0.05). Conclusion The levels of serum PAI-1,TSP-1 and D-D in patients with RSA are highly expressed,which has a certain clinical value for RSA pregnancy outcome.