脂肪因子、炎症因子与胰岛素抵抗分子机制研究进展

A review on molecular mechanism of adipokines,inflammatory factors and insulin resistance

胰岛素是一种非常重要的生物活性物质,在人体外周和中枢组织的能量产生与代谢、细胞生存与增殖中发挥着重要作用。胰岛素抵抗是2型糖尿病(Type 2 Diabetes Mellitus,T2DM)发病机制中的基本机制。近年来有大量研究发布了其发病因素,特别是脂肪因子、炎症因子所诱导的胰岛素抵抗。本文通过综述的形式分析讨论了与胰岛素相关的功能和分子机制,以及与其作用机制关系密切的脂肪因子和炎症因子机制。

Insulin is a very important biologically active substance,which plays an important role in the energy production and metabolism,cell survival and proliferation of the human body’s peripheral and central tissues.Insulin resistance is the basic pathogenesis mechanism of type 2 diabetes mellitus.In recent years,a large number of studies have published its pathogenic factors,especially the insulin resistance induced by adipokines and inflammatory factors.In this article,a review on functions and molecular mechanisms related to insulin was given,and the mechanism of adipokines and inflammatory factors that are closely related to action mechanisms of insulin were discussed.