CT引导三叉神经半月节高电压与标准电压脉冲射频对眼支带状疱疹后神经痛的临床疗效

The clinical effect of CT-guided high voltage pulsed radiofrequency and standard voltage pulsed radiofrequency of trigeminal semilunar ganglion for postherpetic neuralgia in ophthalmic nerve

目的:比较CT引导三叉神经半月节高电压与标准电压脉冲射频对眼支受累带状疱疹后神经痛(postherpetic neuralgia, PHN)的临床疗效。方法:选取眼支PHN病人60例,按随机数字表法平均分为高电压组(H组)和标准电压组(B组);记录两组病人治疗前、治疗后3天、1周、4周、8周、12周视觉模拟评分法(visual analogue scale, VAS)评分;补救治疗次数≥2次例数;8周、12周时疗效评定及不良反应发生情况。结果:两组治疗后各时间点VAS评分均较术前降低。治疗后3天、1周、4周时VAS评分无显著性差异,8周、12周VAS评分明显降低。H组补救治疗例数较B组减少;H组治疗后8周、12周疗效评定优于B组。结论:CT引导下三叉神经半月节高电压脉冲射频对眼支PHN安全有效,可应用于临床。

Objective: To evaluate the effect of CT-guided high voltage pulsed radiofrequency and standard voltage pulsed radiofrequency of trigeminal semilunar ganglion for postherpetic neuralgia in ophthalmic nerve. Methods: Sixty patients with postherpetic neuralgia in ophthalmic nerve were randomly divided into two groups: high voltage group(H) and standard voltage group(B). Visual analogue scale(VAS) before treatment, 3 days, 1 week, 4 weeks, 8 weeks and 12 weeks after treatment were recorded in the two groups, the number of remedial treatment ≥ 2 times. Efficacy evaluation and adverse reactions were observed at 8 and 12 weeks, respectively. Results: Compared with the VAS scores before treatment, the VAS scores of the two groups after treatment were significantly lower. At 3 days,1 week, 4 weeks after treatment, the difference of VAS scores was not statistically significant, but at 8 and 12 weeks, the difference were statistically significant. The number of remedial treatment cases in the group H was lower than that in the group B. The clinical effect in group H was better than group B. Conclusion: CT-guided high voltage pulsed radiofrequency is safe and effective to treat the postherpetic neuralgia in ophthalmic nerve.