吹扫捕集-气相色谱-串联质谱法测定儿童防护口罩中环氧乙烷、环氧丙烷

Determination of ethylene oxide and propylene oxide in protective masks for children by purge-and-trap–gas chromatography–tandem mass spectrometry

采用吹扫捕集–气相色谱–串联质谱(P&T–GC–MS/MS)技术了测定儿童防护口罩中环氧乙烷、环氧丙烷的方法。样品采用4%乙酸水溶液作为模拟液浸泡处理,浸泡液中目标物通过吹扫富集于捕集管中,热脱附后进入气相色谱,采用DB–624 UI型色谱柱(60 m×0.25 mm,1.40μm)分离,气相色谱串联质谱多反应监控模式进行分析检测,内标法定量。环氧乙烷、环氧丙烷在质量浓度为0.2-15 ng/mL范围内与色谱峰面积线性关系良好,环氧乙烷、环氧丙烷的相关系数分别为0.9998、0.9975,方法定量限均为0.01μg/g,满足GB/T 38880—2020及国外相关标准的限值要求。样品加标回收率为91.5%-115.7%,测定结果的相对标准偏差不大于4.9%(n=6)。该方法适用于儿童防护口罩中环氧乙烷、环氧丙烷消毒有效成分的批量测定。

A method for the determination of ethylene oxide and propylene oxide in protective masks for children by purge-and-trap coupled with gas chromatography–tandem mass spectrometry(P&T–GC–MS/MS)was established.The samples were soaked with 4%acetic acid as the simulated soaking solution.The target substances were enriched by the purge-and-trap,injected into gas chromatography after thermal desorption,separated on a DB–624 UI column(60 m×0.25 mm,1.4μm),analysed by multi-reaction monitoring mode,and quantified by internal standard.The mass concentration of ethylene oxide and propylene oxide had good linear relationships with their chromatographic peak area in the range of 0.2–15 ng/mL,with the correlation coefficients was 0.9998 and 0.9975,respectively,the limits of quantitation were all 0.01μg/gwhich could meet the limit requirements of GB/T 38880—2020 and relevant foreign standards.The spiked recoveries of samples was 91.5%–115.7%,and the relative standard deviations were not more than 4.9%(n=6).The method is suitable for the batch determination of ethylene oxide and propylene oxide in children’s protective masks.