寒凝血瘀型原发性痛经穴位敷贴药物组方优化研究

Optimization of Formulations for the Treatment of Primary Dysmenorrhea of Cold Coagulation and Blood Stasis Pattern by Acupoint Application

目的:探讨寒凝血瘀型原发性痛经(primary dysmenorrhea,PD)穴位敷贴治疗药物的组方选择。方法:将寒凝血瘀型PD患者60例随机分为对照组、治疗组各30例。两组药物分别按相应比例、组方进行配伍制备;两组取穴、贴敷时间相同;治疗结束及停止治疗3月后评估月经周期5~10天时患者中医证候、痛经疼痛评分、红外线热扫描结果。结果:两组中医证候及痛经疼痛评分、红外线热扫描结果均较治疗前改善(P<O.05),治疗组改善更明显(P<O.05)。治疗3个月后与治疗结束时疗效比较差异无统计学意义(P>O.05)。结论:在传统发泡组方基础上加入温经散寒行气的药物穴位敷贴治疗寒凝血瘀型痛经具有较好的临床疗效。

Objective:To investigate the prescription selection for the treatment of cold coagulation and blood stasis pattern primary dysmenorrhea by acupoint application.Methods:Sixty patients were randomized into the control group and the treatment group,30 cases in each group.The compatibility and preparation of the drugs for both groups were conducted according to the corresponding ratio and the prescriptions respectively;the acupoints selected and the time of application were the same in both groups;to assess TCM syndrome,dysmenorrhea pain scores,infrared thermal scan results from the fifth day to tenth day of menstrual cycle by the end of the treatment and three months after ceasing the treatment.Results:The scores of TCM syndrome and dysmenorrhea pain,infrared thermal scan results of both groups improved compared with these before treating(P<0.05),the improvements of the treatment group were more notable(P<0.05).The difference had no statistical meaning in clinical effects after three months of the treatment and by the end of the therapy(P>0.05).Conclusion:Based on traditional foaming formulation,the use of the drugs of menstruation-warming cold-dissipating Qi-moving in acupoint application owns better clinical effects.