罗氏风痰咳嗽方治疗风痰阻肺型感染后咳嗽临床研究

Clinical study on wind-phlegm cough formula for postinfectious cough of wind-phlegm obstructing lung

目的观察罗氏风痰咳嗽方治疗风痰阻肺型感染后咳嗽(PIC)的临床疗效。方法将101例风痰阻肺型PIC患者按照随机数字表法分为2组,治疗组51例予罗氏风痰咳嗽方口服,对照组50例予复方甲氧那明胶囊口服,2组均治疗10 d,治疗结束7 d后随访。比较2组疗效及随访时疗效;观察2组治疗前后及随访时中医证候评分变化,莱斯特咳嗽问卷(LCQ)评分变化;记录2组患者不良反应发生情况。结果治疗组总有效率92.2%(47/51),对照组总有效率90.0%(45/50),2组疗效相当(P>0.05)。治疗组随访时总有效率90.2%(46/51),对照组随访时总有效率72.0%(36/50),治疗组远期疗效优于对照组(P<0.05)。2组治疗后、随访时中医证候咳嗽、咯痰、气促、咽喉痒、胸闷评分及总评分均较本组治疗前降低(P<0.05),且治疗组随访时中医证候咳嗽、咯痰、气促、咽喉痒、胸闷评分及总评分均低于对照组(P<0.05)。2组治疗后、随访时LCQ评分均较本组治疗前升高(P<0.05),且治疗组随访时LCQ评分高于对照组(P<0.05)。治疗组不良反应发生率2.0%(1/51),对照组不良反应发生率16.0%(8/50),2组不良反应发生率比较差异有统计学意义(P<0.05)。结论罗氏风痰咳嗽方治疗风痰阻肺型PIC,可明显改善患者临床症状,提高生活质量,且不良反应少,远期疗效优于复方甲氧那明胶囊口服治疗。

Objective To observe the clinical efficacy of wind-phlegm cough formula for postinfectious cough(PIC)of Wind-phlegm obstructing lung.Methods Totally 101 patients with PIC(Wind-phlegm obstructing lung)were randomly divided into treatment group and control group,51 cases in treatment group were orally given wind-phlegm cough formula,50 cases in control group were given compound methoxyphenamine capsules.The treatment continued for 10 days,and followed up were performed for 7 days.The key observation was curative effect,traditional Chinese medicine(TCM)syndrome score,Leicester cough quality(LCQ),adverse reaction rate before and after treatment,as well as at follow-up.Results The total effective rates in treatment group and control group were 92.2%(47/51)and 90%(45/50),respectively,with simitar efficacy in groups(P>0.05);the follow-up total effective rates in treatment group were better than those in control group[90.2%(46/51)vs 72.0%(36/50);(P<0.05),respectively].After treatment,the TCM syndrome score(cough,expectoration,panting;throat itching,chest discomfort)in groups was improved compared with those before treatment(P<0.05),improvement of follow-up TCM syndrome score in treatment group was better than that in control group(P<0.05).LCQ score in groups was obviously higher compared with those before treatment;follow-up LCQ score was higher in treatment group than that in control group(P<0.05).There was a statistically significant difference in the composition of adverse reaction rate between treatment group and control group[2.0%(1/51)vs 16.0%(8/50);respectively].Conclusion For PIC(wind-phlegm obstructing lung),wind-phlegm cough formula can significantly improve the clinical symptoms and quality-of-life,and has less adverse reactions,its long-term efficacy is better than oral compound methoxyphenamine capsules.