芩蒌清热肃肺汤联合西医常规治疗痰热壅肺型重症肺炎的疗效观察及对患者中医症状、炎症指标水平的影响

Observation of Qilou Qingre Sufei Decoction combined with routine western medicine for severe pneumonia of phlegm-heat obstructing lung and its influence on traditional Chinese medicine symptom and inflammatory factors

目的观察芩蒌清热肃肺汤联合西医常规治疗痰热壅肺型重症肺炎的临床疗效,以及对患者和炎症指标水平的影响。方法将83例痰热壅肺型重症肺炎患者按照随机数字表法分为2组,对照组41例予西医常规治疗,治疗组42例在对照组基础上联合芩蒌清热肃肺汤治疗。2组均治疗10 d后统计疗效,比较2组治疗前后中医症状(包括咳嗽、痰量、痰质、胸痛、发热、口渴、便秘)评分及血清炎症指标[包括白细胞介素-6(IL-6)、降钙素原(PCT)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)]水平变化情况。结果治疗组总有效率85.71%(36/42),对照组65.85%(27/41),治疗组疗效优于对照组(P<0.05)。2组治疗后中医症状咳嗽、痰量、痰质、胸痛发热、口渴、便秘评分及总分与本组治疗前比较均降低(P<0.05),且治疗组治疗后中医症状各项评分及总分均低于对照组(P<0.05)。2组治疗后血清IL-6、PCT、TNF-α、CRP水平与本组治疗前比较均降低(P<0.05),且治疗组治疗后各指标水平均低于对照组(P<0.05)。结论芩蒌清热肃肺汤联合西医常规治疗痰热壅肺型重症肺炎疗效确切,可有效改善患者中医症状,抑制炎性反应,提高临床疗效。

Objective To observe clinical efficacy of Qilou Qingre Sufei Decoction combined with routine western medicine for severe pneumonia(phlegm-heat obstructing lung)and its influence on traditional Chinese medicine(TCM)symptom and inflammatory factors.Methods Totally 83 patients with severe pneumonia(phlegm-heat obstructing lung)were randomly divided into 2 groups,41 cases in control group received routine western medicine,and 42 cases in treatment group received Qilou Qingre Sufei Decoction combined with conventional western medicine.The treatment continued 10 days,the aim was to compare TCM symptom(cough,sputum volume,quality of sputum,chest pain,fever,thirsty,constipation)scores,serum inflammatory factors[interleukin-6(IL-6),procalcitonin(PCT),tumor necrosis factor-α(TNF-α),C reactive protein(CRP)];the curative effect was counted.Results The total effective rates in treatment group and control group were 85.71%(36/42)and 65.85%(27/41),respectively,the curative effect being better in treatment group than control group(P<0.05).After treatment,TCM symptom scores in groups were decreased(P<0.05),which decreased notably in treatment group when compared with cortrol group(P<0.05);serum inflammatory factors in groups decreased remarkably(P<0.05),improvement of which in treatment group were significantly better(P<0.05).Conclusion For patients with severe pneumonia(phlegm-heat obstructing lung),Qilou Qingre Sufei Decoction combined with routine western medicine has definite curative effect,can effectively improve TCM symptom,inhibit inflammatory response,and improve clinical efficacy.