风湿三项指标结合ESR检测在类风湿性关节炎诊断中的价值

The value of three indexes of rheumatism combined with ESR in the diagnosis of rheumatoid arthritis

目的:探讨风湿三项指标血清类风湿因子(RF)、C反应蛋白(CRP)、抗链球菌溶血素“O”(ASO)结合红细胞沉降率(ESR)检测在类风湿性关节炎(RA)患者临床诊断中的应用价值。方法:选择2016年2月~2019年10月我院临床科室收治的89例类风湿性关节炎患者为实验组,同期健康体检的82例健康人员为对照组,采用乳胶增强免疫透射比浊法检测血清RF、CRP、ASO的浓度,采用Westergren法检测ESR,比较两组研究对象的检测结果。结果:实验组RF、CRP、ASO及ESR检测水平显著高于对照组,两组比较差异具有统计学意义(P<0.05)。四种指标中单项特异度最高的是ASO(86.22%),单项灵敏度最高的是RF(82.43%)。联合四种指标检测的特异度和灵敏度显著高于单项检测(P<0.05)。结论:联合检测血清中RF、CRP、AS0及ESR水平具有更高的特异度和灵敏度,有利于RA患者的早期诊断及治疗,能显著减少漏诊及误诊率,有比较重要的临床价值。

Objective:Investigate the clinical value of serum rheumatoid factor(RF)、c-reactive protein(CRP)、anti-streptococcus hemolysin"O"(ASO)combined with erythrocyte sedimentation rate(ESR)in the diagnosis of patients with rheumatoid arthritis(RA).Methods:Chose 89 cases with rheumatoid arthritis treated in our hospital from February 2016 to october 2019 as an experimental,the 82 healthy people who underwent physical examination during the same period as a control group,to use latex-enhanced immunotransmittance turbidimetry assay for Serum RF、CRP、ASO concentration,to use Westergren assay for ESR,and compared the test results of the two groups.Results:The detection levels of RF、CRP、ASO and ESR in the experimental group were significantly higher than those in the control group,there was significant difference between the two groups(P<0.05).ASO was the highest single specificity(86.22%).RF was the highest single sensitivity(82.43%).The specificity and sensitivity of combined detection of four indexes were significantly higher than single detection(P<0.05).Conclusion:Combined detection of serum RF、CRP、ASO and ESR had higher specificity and sensitivity,it is beneficial to the early diagnosis and treatment of RA patients,can significantly reduce the rate of missed diagnosis and misdiagnosis and has important clinical value.