8052例受血者血型不规则抗体检测结果的回顾性分析

Retrospective Analysis of Blood Type Irregular Antibody Identification Results in 8052 Patients

目的:对受血者不规则抗体检测结果进行回顾性分析,探讨本地区不规则抗体产生频率、分布特点及未来输血策略。方法:选取2019年1月~12月拟输血患者8052例,统计分析不规则抗体阳性检出率、分布特点及阳性者后续输血情况。结果:不规则抗体阳性检出率0.36%(29/8052),男、女性分别为0.21%(8/3865)、0.50%(21/4/187)(P<0.05),有、无输血史分别为1.02%(20/1966)、0.15%(9/6086)(P<0.05),有、无妊娠史分别为0.65%(19/2915)、0.16%(2/1272)(P<0.05);其中,Rh系统占37.93%(11/29),MNS系统占31.03%(9/29),Lewis系统占6.90%(2/29),其他占24.14%(7/29);24/h内及时有效输血率为62.07%(18/29)。结论:针对本地区受血者不规则抗体分布特点,建立相应特殊血型抗原信息库,完善高频不规则抗体检测及防控措施,可为今后快速精准输血的参考策略。

Objective:The results of irregular antibody test were analyzed retrospectively to investigate the frequency and distribution of irregular antibody production which also make contributions to generating future transfusion strategies in this region.Methods:A total of 8052 patients were selected from January to December 2019.The positive detection rate of irregular antibody,distribution characteristics and follow-up blood transfusion records of positive irregular antibody were statistically analyzed.Results:The positive detection rate of irregular antibody was 0.36%(19/8052).Male and female were account for 0.21%(8/3865)and 0.50%(21/4187)(P<0.05),respectively.Also,the patients with and without transfusion history were 1.02%(20/1966)and 0.15%(9/6086)(P<0.05),respectively.It accounted for 0.65%(19/2915)and 0.16%(2/1272)(P<0.05)respectively according to pregnancy history of patients.Among them,Rh system accounted for 37.93%(11/29),MNS system for 31.03%(9/29),Lewis system for 6.90%(2/29),and others for 24.14%(7/29).In addition,the rate of timely and effective transfusion within 24 hours was 62.07%(18/29).Conclusion:The database of special blood type antigen should be established according to the distribution characteristics of irregular antibody in this region.Also,prevention and control measures should be taken following the improvement of the high-frequency irregular antibodies detection which can be reference strategies for rapid and accurate blood transfusion in the future.