穴位埋线结合温针灸治疗膝骨关节炎的疗效研究

Efficacy of acupoint embedding thread combined with warm acupuncture in treating patients with knee osteoarthritis

目的探讨穴位埋线结合温针灸治疗膝骨关节炎的疗效及对血清IL-1、IL-6、TNF-α水平的影响。方法选取2018年9月—2020年7月在杭州市第一人民医院就诊的膝骨关节炎患者120例,按随机数字表法分为对照组和观察组,各60例。对照组给予双氯芬酸钠缓释片,观察组给予穴位埋线结合温针灸治疗,2组疗程为4周。比较2组患者视觉模拟评分(VAS)、Lysholm量表(LKSS)评分、WOMAC评分、中医临床症状评分、临床疗效、血清IL-1、IL-6、TNF-α水平。结果治疗后,观察组VAS评分[(1.36±0.17)分]、WOMAC评分[(2.72±0.34)分、(0.94±0.14)分、(15.40±2.22)分]以及LKSS评分[(76.13±8.46)分]明显优于对照组[(2.81±0.43)分、(4.31±0.52)分、(1.65±0.22)分、(20.38±2.46)分、(62.01±7.75)分,均P<0.001],中医临床症状评分优于对照组(均P<0.001)。观察组总有效率显著高于对照组(P<0.05)。治疗后,观察组患者血清IL-1[(8.21±1.25)ng/L]、IL-6[(33.61±4.46)ng/L]、TNF-α[(12.09±1.77)ng/L]改善显著优于对照组[(12.13±1.65)ng/L、(54.81±6.03)ng/L、(15.40±2.51)ng/L,均P<0.001]。结论穴位埋线结合温针灸治疗膝骨关节炎的疗效显著,值得在临床推广使用。

Objective To investigate the efficacy of acupoint embedding thread combined with warm acupuncture in treating patients with knee osteoarthritis and its effect on the levels of serum interleukin(IL)-1,IL-6 and tumour necrosis factor(TNF)-α.Methods One hundred twenty patients with knee osteoarthritis admitted in our hospital from September 2017 to July 2020 were selected and divided into control group and observation group with 60 patients in each group using the random number table method.The control group was treated with diclofenac sodium sustained-release tablets,whereas the observation group was treated with acupoint embedding combined with warm acupuncture.The course of treatment of the two groups was 4 weeks.The visual analogue scale(VAS),scores of Lysholm scale(LKSS),WOMAC indexes,symptoms of traditional Chinese medicine,clinical efficacy and serum levels of IL-1,IL-6 and TNF-αwere compared between the two groups.Results After treatment,the VAS[(1.36±0.17)points],scores of LKSS[(76.13±8.46)points]and WOMAC indexes[(2.72±0.34)points,(0.94±0.14)points,(15.40±2.22)points]in the observation group were significantly higher than those in the control group[VAS(2.81±0.43)points,scores of LKSS(62.01±7.75)points,WOMAC indexes(4.31±0.52)points,(1.65±0.22)points,(20.38±2.46)points;all P<0.001],and symptoms of traditional Chinese medicine in the observation group were significantly higher than those in the control group(all P<0.001).The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the improvement of serum IL-1[(8.21±1.25)ng/L],IL-6[(33.61±4.46)ng/L]and TNF-α[(12.09±1.77)ng/L]in the observation group were significantly better than those in the control group[IL-1(12.13±1.65)ng/L,IL-6(54.81±6.03)ng/L,TNF-α(15.40±2.51)ng/L,all P<0.001].Conclusion The efficacy of acupoint embedding thread combined with warm acupuncture in treating patients with knee osteoarthritis is significant,which shows potential application in clinic.