埃索美拉唑与雷贝拉唑分别联合奥瑞凝胶对反流性食管炎患者症状持续时间及胃泌素水平的影响

The effect of esomeprazole and rabeprazole combined with origel on the duration of symptoms and gastrin levels in patients with reflux esophagitis

目的探讨埃索美拉唑与雷贝拉唑分别联合奥瑞凝胶对反流性食管炎患者症状持续时间及胃泌素水平的影响。方法选取2018年2月至2019年10月本院收治的90例反流性食管炎患者作为研究对象,采用随机数字表法分为观察组和对照组,每组45例。对照组采用雷贝拉唑联合奥瑞凝胶治疗,观察组采用埃索美拉唑联合奥瑞凝胶治疗。比较两组中医证候评分、症状持续时间、胃泌素水平。结果治疗8周后,两组腹胀、胃灼热、嗳气症候评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗8周后,两组最长反流持续时间均短于治疗前,且观察组短于对照组,差异有统计学意义(P<0.05)。治疗8周后,两组胃泌素水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论埃索美拉唑与雷贝拉唑分别联合奥瑞凝胶均可有效治疗反流性食管炎,明显改善患者临床症状与胃泌素水平,但埃索美拉唑联合奥瑞凝胶治疗效果更佳。

Objective To investigate the effects of esomeprazole and rabeprazole combined with origel on the duration of symptoms and gastrin levels in patients with reflux esophagitis.Methods 90 patients with reflux esophagitis admitted to our hospital from February 2018 to October 2019 were selected as the research subjects,and they were divided into observation group and control group by random munber table method,with 45 cases in each group.The control group was treated with rabeprazole combined with origel,and the observation group was treated with esomeprazole combined with origel.The scores of TCM syndromes,duration of symptoms,and gastrin levels were compared between the two groups.Results After 8 weeks of treatment,the scores of abdominal distension,heartburn and belching in the two groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After 8 weeks of treatment,the longest duration of reflux in the two groups was shorter than before treatment,and the observation group was shorter than the control group,the difference was statistically significant(P<0.05).After 8 weeks of treatment,the gastrin levels in the two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion Both esomeprazole and rabeprazole combined with origel can effectively treat reflux esophagitis and can significantly improve the clinical symptoms and gastrin levels of patients,but the treatment of esomeprazole combined with oringel is better.