短期强化他汀联合依达拉奉治疗急性脑梗死患者的临床短期效果探讨

Clinical effect of short-term intensive statin combined with edaravone in the treatment of patients with acute cerebral infarction

目的探究短期强化他汀联合依达拉奉治疗急性脑梗死患者的临床短期效果。方法选取本院2018年12月至2019年12月收治的68例急性脑梗死患者作为研究对象,按照是否行短期强化他汀联合依达拉奉治疗分为对照组(阿托伐他汀钙20 mg联合依达拉奉治疗)与实验组(阿托伐他汀钙40 mg联合依达拉奉治疗),每组34例。比较两组炎症因子、血脂参数、生活质量及神经功能。结果治疗2个疗程后,两组C-反应蛋白、白介素-8、肿瘤坏死因子-α水平均低于入院时,且实验组低于对照组,差异有统计学意义(P<0.05)。治疗2个疗程后,实验组血清胆固醇、甘油三酯、高密度脂蛋白水平均低于对照组,差异有统计学意义(P<0.05)。治疗2个疗程后,两组ADL评分均高于入院时,NIHSS评分均低于入院时,且实验组ADL评分高于对照组,NIHSS评分低于对照组,差异有统计学意义(P<0.05)。结论急性脑梗死患者阿托伐他汀钙40 mg联合依达拉奉治疗效果明显优于阿托伐他汀钙20 mg联合依达拉奉治疗,有利于改善患者生活质量和神经功能,值得临床推广应用。

Objective To explore the clinical effect of short-term intensive statin combined with edaravone in the treatment of patients with acute cerebral infarction.Methods 68 patients with acute cerebral infarction treated in our hospital from December 2018 to December 2019 were selected as the research subjects.They were divided into control group(atorvastatin calcium 20 mg combined with Edaravone)and experimental group(atorvastatin calcium 40 mg combined with edaravone)according to whether they were treated with short-term intensive statin combined with edaravone,with 34 cases in each group.The inflammatory factors,blood lipid parameters,quality of life and neurological function were compared between the two groups.Results After 2 courses of treatment,the levels of C-reactive protein,interleukin-8 and tumor necrosis factor-αin the two groups were lower than at admission,and the experimental group were lower than those in the control group(P<0.05).After 2 courses of treatment,the levels of serum cholesterol,triglycerides,and high-density lipoprotein in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.05).After 2 courses of treatment,the ADL score of the two groups were higher than at admission,and the NIHSS score were lower than at admission.The ADL score of the experimental group was higher than that of the control group,and the NIHSS score was lower than that of the control group(P<0.05).Conclusion Atorvastatin calcium 40 mg combined with edaravone is better than atorvastatin calcium 20 mg combined with edaravone in the treatment of acute cerebral infarction,it is beneficial to improve the quality of life and neurological function of patients,which is worthy of clinical application.