血清MMP-2、NRP-l水平预测肺腺癌患者解剖性肺切除术预后的研究

Value of serum MMP-2 and NRP-1 levels in predicting prognosis of anatomical pneumonectomy for lung adenocarcinoma

目的分析血清金属基质蛋白酶-2(MMP-2)、神经纤毛蛋白-1 (NRP-1)水平预测肺腺癌患者解剖性肺切除术预后的价值。方法前瞻抽取2019年1月至2019年12月于平顶山市第一人民医院接受解剖性肺切除术治疗的100例肺腺癌患者, 全部患者术后均随访1年, 依据患者随访期间有无发生复发、转移及病死等情况, 分为预后不良组和预后良好组。比较两组患者术前1天的血清MMP-2、NRP-l水平, 分析其预测肺腺癌患者解剖性肺切除术治疗预后的价值。结果随访结束时, 100例接受解剖性肺切除术治疗的肺腺癌患者中, 预后不良患者16例, 预后不良占比为16.00%, 纳入预后不良组, 其他84例患者纳入预后良好组。预后不良组血清MMP-2、NRP-1水平高于预后良好组(P<0.05)。绘制受试者工作特征曲线(ROC曲线), 腺癌患者术前1天血清MMP-2、NRP-l水平预测预后风险的曲线下面积(AUC)>0.70, 预测价值较理想, 且患者术前1天血清MMP-2、NRP-l水平cut-off值取374.165 μg/L、3.265 ng/ml时, 联合预测价值最好。结论血清MMP-2、NRP-l水平预测肺腺癌患者解剖性肺切除术治疗预后的价值较高, 可用于早期预测肺腺癌患者解剖性肺切除术后的预后情况。

Objective To analyze the value of serum levels of matrix metalloproteinase-2(MMP-2),neuropilin-1(NRP-1)in predicting the prognosis of anatomical pneumonectomy for lung adenocarcinoma.Methods A total of 100 patients with lung adenocarcinoma who underwent anatomical pneumonectomy in Pingdingshan First People’s Hospital from January 2019 to December 2019 were prospectively selected,all patients were followed up for 1 year after operation,according to the recurrence,metastasis and mortality during the follow-up period,the patients were divided into the poor prognosis group and the good prognosis group.The levels of MMP-2 and NRP-1 in serum were compared between the two groups,the value of levels of MMP-2 and NRP-1 in serum in predicting the prognosis of patients with lung adenocarcinoma after anatomical pneumonectomy was mainly analyzed.Results At the end of follow-up,there were 16 patients with poor prognosis,accounting for 16.00%,and they were included into the poor prognosis group,the other 84 patients were included into the good prognosis group.The levels of MMP-2 and NRP-1 in serum of the poor prognosis group were higher than those of the good prognosis group one day before operation(P<0.05);the receiver operating characteristic(ROC)curre was drawn,the area under the curve(AUC)of serum MMP-2 and NRP-1 levels one day before operation in predicting the risk of prognosis of patients with adenocarcinoma after anatomical pneumonectomy were>0.70,which had ideal predictive value,the cut-off value of serum MMP-2 and NRP-1 of patients one day before operation were 374.165μg/L,3.265 ng/ml,the combined predictive value was the best.Conclusions The serum levels of MMP-2 and NRP-1 have high value in predicting the prognosis of patients with lung adenocarcinoma after anatomical pneumonectomy,which can be used to predict the prognosis of patients with lung adenocarcinoma after anatomical pneumonectomy in the early period.