联合使用布拉氏酵母菌的五联方案与四联标准方案根除幽门螺杆菌的疗效比较

Comparison of the efficacy of five combination regimens of combined Saccharomvces boulardii sachets versus four combination standard regimens in the eradication of Helicobacter pylori

目的比较联合使用布拉氏酵母菌(亿活)的五联方案和四联标准方案根除幽门螺杆菌(Hp)的临床效果。方法抽取2020年6月至2021年5月收山西医科大学附属太原市中心医院治的603例Hp感染患者作为研究对象, 按照随机数字表法进行分组, 对照组(298例)行四联标准治疗, 观察组(305例)给予布拉氏酵母菌五联方案治疗。比较两组患者治疗前后临床症状、血清炎症因子白细胞介素-2(IL-2)、C-反应蛋白(CRP)水平改善情况, 检测两组Hp根除率, 随访不良反应发生情况。结果治疗前两组患者上腹疼痛、腹胀、恶心等症状积分比较差异未见统计学意义(P>0.05), 治疗后治疗后两组患者各项症状积分低于治疗前(P<0.05), 且观察组各项症状积分低于对照组(P<0.05);治疗前两组IL-2、CRP水平比较, P>0.05;治疗后两组患者IL-2、CRP水平高于治疗前(P<0.05), 且观察组较对照组改善明显(P<0.05);观察组Hp根除率为98.03%, 高于对照组的91.95%(P<0.05);观察组不良反应发生率(1.31%)低于对照组的4.03%(P<0.05)。结论联合使用布拉氏酵母菌(亿活)五联根除Hp成功率高, 在改善患者临床症状及炎症因子水平方面效果较好, 且不良反应少。

Objective To compare the clinical efficacy of five combination regimens of combined Saccharomvces boulardii sachets and four combination standard regimens in the eradication of Helicobacter pylori(Hp).Methods A total of 603 patients with HP infection in Taiyuan Central Hospital Affiliated to Shanxi Medical University from June 2020 to May 2021 were selected as the research objects and randomly divided into two groups.The control group(298 cases)was treated with four combination standard regimens,and the observation group(305 cases)was treated with five combination regimens of combined Saccharomvces boulardii sachets.The clinical symptoms,serum inflammatory factors including interleukin-2(IL-2),C-reactive protein(CRP)levels were compared between the two groups before and after treatment.The Hp eradication rate of the two groups was detected,and the occurrence of adverse reactions was followed up.Results There was no significant difference in the symptom scores of upper abdominal pain,abdominal distension and nausea between the two groups before treatment(P>0.05);after treatment,the symptom scores of the two groups were lower than those before treatment(P<0.05),and the symptom scores of the observation group were lower than those of the control group(P<0.05).There was no difference in the levels of IL-2 and CRP between the two groups before treatment(P>0.05);after treatment,the levels of IL-2 and CRP in the two groups were higher than those before treatment(P<0.05),and the levels of IL-2 and CRP of the observation group improved significantly compared with those of the control group(P<0.05).The eradication rate of HP in the observation group was 98.03%,which was higher than 91.95%in the control group(P<0.05);the incidence of adverse reactions in the observation group(1.31%)was lower than that in the control group(4.03%),P<0.05.Conclusions Five combination regimens of combined Saccharomvces boulardii sachets quintuple eradication of HP has a high success rate,has a good effect in improving the clinical symptoms and inflammatory factor levels of patients,and has less adverse reactions.