血清hs-CRP、MMP-9水平与晚期肺癌患者血小板输注效果的相关性分析

Correlation between serum hs-CRP,MMP-9 levels and effect of platelet transfusion in patients with advanced lung cancer

目的探讨血清超敏-C反应蛋白(hs-CRP)、金属基质蛋白酶-9(MMP-9)水平与晚期肺癌患者血小板输注效果的相关性。方法抽取河南科技大学第一附属医院于2017年8月至2021年2月实施血小板输注治疗的晚期肺癌患者60例, 血小板增加指数(CCI)>7.5为有效, 根据血小板输注后是否有输注疗效分为输注有效组(49例)和输注无效组(11例), 比较两组患者血小板输注前后血清hs-CRP和MMP-9水平的变化, 采用Spearman相关性分析了解血清hs-CRP和MMP-9水平与晚期肺癌患者血小板输注后输注疗效之间的相关性, 采用受试者工作特征曲线(ROC曲线)评价血清hs-CRP和MMP-9水平预测晚期肺癌患者血小板输注疗效的效能。结果输血前后, 输注有效组患者的MMP-9和hs-CRP水平高于输注无效组(P<0.05);Spearman相关性分析结果显示, 血清MMP-9和hs-CRP水平与晚期肺癌患者血小板输注疗效呈正相关(r=0.816、0.823, P<0.05);以血清MMP-9和hs-CRP指标单独检测及联合检测作为检验变量, 血小板输注后是否有效作为状态变量进行ROC曲线分析, 曲线下面积(AUC)=0.725、0.727、0.887, P<0.05;MMP-9和hs-CRP指标联合检测的灵敏度和特异性均高于各项指标单独检测(P<0.05)。结论血小板输注可有效治疗晚期肺癌患者化疗后导致的血小板减少, 且患者的hs-CRP、MMP-9指标与血小板输注是否有效呈正相关。

Objective To investigate the correlation between high-sensitivity C-reactive protein(hs-CRP),matrix metalloproteinase-9(MMP-9)levels and clinical curative effect in patients with advanced lung cancer undergoing platelet transfusion.Methods A total of 60 patients with advanced lung cancer undergoing platelet transfusion in the First Affiliated Hospital of Henan University of Science and Technology were enrolled between August 2017 and February 2021 Corrected count increment(CCI)over 7.5 was effective,according to presence or absence of effective platelet transfusion,they were divided into effective transfusion group(49 cases)and ineffective transfusion group(11 cases).The changes in levels of serum hs-CRP and MMP-9 before and after platelet transfusion between the two groups were compared.The correlation between serum hs-CRP,MMP-9 levels and transfusion effect in patients with advanced lung cancer was analyzed by Spearman correlation analysis.The predictive efficiency of serum hs-CRP and MMP-9 levels for platelet transfusion effect was evaluated by receiver operating characteristic(ROC)curve.Results Before and after blood transfusion,levels of MMP-9 and hs-CRP in effective transfusion group were significantly higher than those in ineffective transfusion group(P<0.05).The results of Spearman correlation analysis showed that levels of serum MMP-9 and hs-CRP were positively correlated with platelet transfusion effect(r=0.816,0.823,P<0.05).MMP-9 and hs-CRP indicators were tested individually and combined as test variables,and whether platelet transfusion was effective as a state variable was analyzed by ROC curve,area under the curve(AUC)=0.725,0.727,0.887,P<0.05.The sensitivity and specificity of serum MMP-9 combined with hs-CRP were higher than those of single index(P<0.05).Conclusions Platelet transfusion can effectively treat chemotherapy-induced thrombocytopenia in patients with advanced lung cancer.The hs-CRP and MMP-9 are positively correlated with platelet transfusion effect.